患有IgA肾病和与相同HL-A抗原相关的弥漫性增殖性肾小球肾炎（PGN）的兄弟姐妹。

Siblings with IgA nephropathy and diffuse proliferative glomerulonephritis (PGN) associated with identical HL-A antigens.

作者信息

Miura M, Tomino Y, Yagame M, Suga T, Endoh M, Nomoto Y, Sakai H

机构信息

Department of Internal Medicine, School of Medicine, Tokai University, Japan.

出版信息

Tokai J Exp Clin Med. 1986 Nov;11(5):323-7.

PMID:3313816

Abstract

Siblings with IgA nephropathy and diffuse proliferative glomerulonephritis without mesangial IgA deposits (PGN) who had identical HL-A antigens are described. A 21-year-old woman suffered from IgA nephropathy and her 27-year-old sister showed diffuse proliferative glomerulonephritis (PGN) distinct from IgA nephropathy. These siblings had identical HL-A alloantigens which were A2, Aw24; Bw16, Bw35; Cw4, Cw7; DR4. Microhematuria and increased serum IgA levels were shown in their father and other sister but renal biopsies were not performed. The serotypes for the HL-A antigens of their father and other sister were A2, Aw24; Bw27, Bw35; Cw4; DR4 and A2; Bw16; Cw7; Dr2, respectively. It is demonstrated that IgA nephropathy and PGN share a common HL-A phenotype including DR4. It is postulated that the presence of DR4 antigens is not directly related to the occurrence of IgA nephropathy.

摘要

本文描述了患有IgA肾病和无系膜IgA沉积的弥漫性增生性肾小球肾炎（PGN）且具有相同HL-A抗原的兄弟姐妹。一名21岁女性患有IgA肾病，她27岁的姐姐表现为与IgA肾病不同的弥漫性增生性肾小球肾炎（PGN）。这些兄弟姐妹具有相同的HL-A同种抗原，即A2、Aw24；Bw16、Bw35；Cw4、Cw7；DR4。他们的父亲和另一个姐姐有镜下血尿和血清IgA水平升高，但未进行肾活检。他们父亲和另一个姐姐的HL-A抗原血清型分别为A2、Aw24；Bw27、Bw35；Cw4；DR4和A2；Bw16；Cw7；Dr2。结果表明，IgA肾病和PGN具有包括DR4在内的共同HL-A表型。据推测，DR4抗原的存在与IgA肾病的发生没有直接关系。