The First Clinical Medical College, Lanzhou University , Lanzhou, China.
Department of Gastroenterology, The First Hospital of Lanzhou University , Lanzhou, China.
Expert Rev Mol Diagn. 2020 Oct;20(10):1051-1062. doi: 10.1080/14737159.2020.1822169. Epub 2020 Nov 2.
This meta-analysis aims to explore the diagnostic value and accuracy of circulating lncRNAs as biomarkers of digestive system tumors.
PubMed, Embase, Cochrane Library, and Web of science were searched for relevant articles that were published before April 2019, and a meta-analysis was conducted.
52 studies with 63 lncRNAs were discussed in the meta-analysis. The pooled sensitivity and specificity of diagnosis were 0.80 (95% CI: 0.79-0.81) and 0.76 (95% CI: 0.75-0.77), respectively. The pooled DOR (the diagnostic odds ratio) was 15.63 (95% CI: 12.77-19.12), and the overall AUC (the area under the curve) was 0.87. Besides, subgroup analyzes showed that the DOR and AUC of large sample sizes (>80), multiple lncRNAs, serum-based lncRNAs, and downregulation group were superior to those of small sample sizes (≤80), single lncRNA, plasma-based lncRNAs, and upregulation group, respectively. The current data also highlight that the diagnostic accuracy of circulating lncRNAs in the case of colorectal cancer was higher than gastric cancer, hepatocellular carcinoma, esophageal carcinoma, and pancreatic cancer. And there is no difference in the perspective of geographical regions.
The circulating lncRNAs have high diagnostic value and accuracy in digestive system cancers and may serve as potential biomarkers.
本荟萃分析旨在探讨循环长链非编码 RNA 作为消化系统肿瘤标志物的诊断价值和准确性。
检索 PubMed、Embase、Cochrane 图书馆和 Web of science 中截至 2019 年 4 月前发表的相关文章，并进行荟萃分析。
荟萃分析共纳入 52 项研究，涉及 63 个长链非编码 RNA。诊断的汇总敏感性和特异性分别为 0.80（95%CI：0.79-0.81）和 0.76（95%CI：0.75-0.77）。汇总诊断比值比（DOR）为 15.63（95%CI：12.77-19.12），总体 AUC（曲线下面积）为 0.87。此外，亚组分析表明，大样本量（>80）、多个长链非编码 RNA、基于血清的长链非编码 RNA 和下调组的 DOR 和 AUC 优于小样本量（≤80）、单个长链非编码 RNA、基于血浆的长链非编码 RNA 和上调组。目前的数据还表明，循环长链非编码 RNA 在结直肠癌中的诊断准确性高于胃癌、肝细胞癌、食管癌和胰腺癌。并且从地理位置来看，没有差异。
循环长链非编码 RNA 对消化系统癌症具有较高的诊断价值和准确性，可能作为潜在的生物标志物。
