Department of Anatomy, Embryology Laboratory, Yonsei University College of Medicine, Seoul, Korea.
Curr Med Chem. 2021;28(25):5084-5097. doi: 10.2174/0929867327666201102115327.
HOX genes belong to the highly conserved homeobox superfamily, responsible for the regulation of various cellular processes that control cell homeostasis, from embryogenesis to carcinogenesis. The abnormal expression of HOX genes is observed in various cancers, including breast cancer, where they act as oncogenes or as suppressors of cancer, according to context. In this review, we analyze HOX gene expression patterns in breast cancer and examine their relationship, based on the three-dimensional genome structure of the HOX locus. The presence of non-coding RNAs embedded within the HOX cluster and the role of these molecules in breast cancer, have been reviewed. We further evaluate the characteristic activity of HOX protein in breast cancer and its therapeutic potential.
HOX 基因属于高度保守的同源盒超家族，负责调节从胚胎发生到癌变等各种控制细胞内稳态的细胞过程。HOX 基因的异常表达在包括乳腺癌在内的各种癌症中都有观察到，根据具体情况，它们可以作为癌基因或抑癌基因发挥作用。在这篇综述中，我们分析了乳腺癌中 HOX 基因的表达模式，并根据 HOX 基因座的三维基因组结构研究了它们之间的关系。还综述了嵌入 HOX 簇内的非编码 RNA 的存在及其在乳腺癌中的作用。我们进一步评估了 HOX 蛋白在乳腺癌中的特征活性及其治疗潜力。
