Wu Huixiang, Xiao Kang, Ouyang Ting, Wang Zhu, Chen Yibo, Li Nan, Liu Zhao-Qing
School of Chemistry and Chemical Engineering/Institute of Clean Energy and Materials/Guangzhou Key Laboratory for Clean Energy and Materials/Key Laboratory for Water Quality and Conservation of the Pearl River Delta, Ministry of Education, Guangzhou University, Guangzhou Higher Education Mega Center, No. 230 Wai Huan Xi Road, 510006, PR China.
School of Chemistry and Chemical Engineering/Institute of Clean Energy and Materials/Guangzhou Key Laboratory for Clean Energy and Materials/Key Laboratory for Water Quality and Conservation of the Pearl River Delta, Ministry of Education, Guangzhou University, Guangzhou Higher Education Mega Center, No. 230 Wai Huan Xi Road, 510006, PR China.
J Colloid Interface Sci. 2021 Mar;585:605-613. doi: 10.1016/j.jcis.2020.10.040. Epub 2020 Oct 20.
Hydrogen peroxide (HO) is a significant biomarker in physiological processes. Abnormal levels of HO are considered to be closely related to some acute diseases. Therefore, it is important to monitor the HO levels in bio-samples. Herein, we present a novel non-enzymatic electrochemical HO sensor based on the excellent electrocatalytic performance of a composite comprising Zn-Cr-Co ternary spinel metal oxide nanodots (ZnCrCoO) anchored on the surface of nitrogen-doped carbon nanotubes (NCNTs), denoted as ZnCrCoO/NCNTs, toward HO reduction. ZnCrCoO/NCNTs were synthesized using a facile one-pot hydrothermal strategy. The enhanced electrocatalytic performance of ZnCrCoO is resulted from the partial substitution of Co in spinel zinc cobaltate (ZnCoO) with Cr, which modifies the CoO electronic structure and enhances electroconductivity. The ZnCrCoO/NCNTs-based HO sensor exhibited a wide quantitative detection range from 1 to 7330 μM with a detection limit of 1 μM. The sensor showed excellent reproducibility and selectivity for HO sensing. In addition, remarkable recoveries were obtained for HO-spiked fish serum samples. These results demonstrated that the as-developed sensor has a great potential in monitoring HO levels in practical applications.
过氧化氢（HO）是生理过程中的一种重要生物标志物。HO水平异常被认为与一些急性疾病密切相关。因此，监测生物样品中的HO水平很重要。在此，我们基于一种复合材料的优异电催化性能，提出了一种新型非酶电化学HO传感器，该复合材料由锚定在氮掺杂碳纳米管（NCNTs）表面的Zn-Cr-Co三元尖晶石金属氧化物纳米点（ZnCrCoO）组成，记为ZnCrCoO/NCNTs，用于HO还原。采用简便的一锅水热法合成了ZnCrCoO/NCNTs。ZnCrCoO电催化性能的增强源于尖晶石锌钴酸盐（ZnCoO）中的Co被Cr部分取代，这改变了CoO的电子结构并提高了电导率。基于ZnCrCoO/NCNTs的HO传感器具有1至7330 μM的宽定量检测范围，检测限为1 μM。该传感器对HO传感表现出优异的重现性和选择性。此外，加标HO的鱼血清样品获得了显著的回收率。这些结果表明，所开发的传感器在实际应用中监测HO水平具有巨大潜力。
