Department of Nuclear Cardiology, National Institute of Cardiology Ignacio Chavez, Mexico City, Mexico.
Department of Echocardiography, ABC Medical Center, Mexico City, Mexico.
Future Cardiol. 2021 Sep;17(6):985-990. doi: 10.2217/fca-2020-0145. Epub 2020 Nov 3.
Antiphospholipid syndrome (APS) can occur as a primary disease or secondary to an underlying disease, such as systemic lupus erythematosus, or other systemic autoimmune diseases. Catastrophic APS refers to a rapid progression of the disease with the development of thrombotic events that affect three or more organs. This is the case of a 22-year-old woman without history of pregnancy. She developed a catastrophic APS associated with systemic lupus erythematosus, with kidney damage (focal lupus nephritis III), pulmonary embolism, and Libman-Sacks mitral valve endocarditis. Accurate diagnosis and optimal medical treatment (anticoagulants, corticosteroids, antimalarials, diuretics) improved her disease, and the patient was discharged in good clinical condition and continues her multidisciplinary follow-up in the outpatient clinic of our institution.
抗磷脂综合征（APS）可作为一种原发性疾病或继发于某种基础疾病，如系统性红斑狼疮或其他系统性自身免疫性疾病。灾难性 APS 是指疾病迅速进展，发生影响三个或更多器官的血栓事件。这是一位 22 岁、无妊娠史的女性患者，患有与系统性红斑狼疮相关的灾难性 APS，伴有肾脏损害（局灶节段性狼疮性肾炎 III 型）、肺栓塞和利伯曼-萨克斯二尖瓣心内膜炎。准确的诊断和最佳的药物治疗（抗凝剂、皮质类固醇、抗疟药、利尿剂）改善了她的病情，患者出院时临床状况良好，并继续在我院的多学科门诊进行随访。
