使用同位素标记研究高光毒性铂金属卟啉的细胞分布。
Studying the cellular distribution of highly phototoxic platinated metalloporphyrins using isotope labelling.
机构信息
Department of Chemistry, University of Zurich, Zurich CH 8057, Switzerland.
出版信息
Chem Commun (Camb). 2020 Nov 19;56(92):14373-14376. doi: 10.1039/d0cc05196a.
PMID:33140750
Abstract
Novel tetraplatinated metalloporphyrin-based photosensitizers (PSs) are reported, which show excellent phototoxic indexes (PIs) up to 5800 against HeLa cells, which is, to the best of our knowledge, the highest value reported for any porphyrin so far. Furthermore, 67Zn isotope labelling allowed the determination of the ratio of zinc to platinum inside the cells using ICP-MS.
摘要
新型四配位铂金属卟啉类光敏剂（PSs）被报道，其对 HeLa 细胞的光毒性指数（PI）高达 5800，据我们所知，这是迄今为止报道的任何卟啉类化合物中的最高值。此外，67Zn 同位素标记允许使用 ICP-MS 测定细胞内锌与铂的比例。
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