解析阳离子苯并卟啉类光动力剂对膀胱癌细胞的光动力活性。

LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal.

Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal.

Molecules. 2021 Sep 1;26(17):5312. doi: 10.3390/molecules26175312.

In this study, we report the preparation of new mono-charged benzoporphyrin complexes by reaction of the appropriate neutral benzoporphyrin with (2,2'-bipyridine)dichloroplatinum(II) and of the analogs' derivatives synthesized through alkylation of the neutral scaffold with iodomethane. All derivatives were incorporated into polyvinylpyrrolidone (PVP) micelles. The ability of the resultant formulations to generate reactive oxygen species was evaluated, mainly the singlet oxygen formation. Then, the capability of the PVP formulations to act as photosensitizers against bladder cancer cells was assessed. Some of the studied formulations were the most active photosensitizers causing a decrease in HT-1376 cells' viability. This creates an avenue to further studies related to bladder cancer cells.

在这项研究中，我们通过用（2,2'-联吡啶）二氯铂（II）与适当的中性苯并卟啉反应，以及用碘甲烷对中性支架进行烷基化来合成类似物的衍生物，制备了新的单电荷苯并卟啉配合物。所有衍生物都被掺入聚乙烯吡咯烷酮（PVP）胶束中。评估了所得制剂产生活性氧的能力，主要是单线态氧的形成。然后，评估了 PVP 制剂作为膀胱癌细胞光动力治疗剂的能力。一些研究制剂是最有效的光动力治疗剂，导致 HT-1376 细胞活力下降。这为进一步研究膀胱癌细胞开辟了道路。