英夫利昔单抗治疗下溃疡性结肠炎患者的 IgA 血管炎：药物诱导还是遗传？
IgA vasculitis in a patient with ulcerative colitis under infliximab: drug-induced or genetic?
机构信息
Division of Gastroenterology, Department of Internal Medicine, School of Medicine, Iwate Medical University, Morioka, Japan.
Division of Molecular Diagnostic Pathology, Department of Pathology, School of Medicine, Iwate Medical University, Morioka, Japan.
出版信息
Clin J Gastroenterol. 2021 Feb;14(1):198-203. doi: 10.1007/s12328-020-01280-8. Epub 2020 Nov 3.
We present the case of a 17-year-old male patient with ulcerative colitis (UC) under infliximab therapy and a family history of IgA vasculitis (IgAV). During a maintenance infliximab session, he developed palpable purpura, abdominal pain, and hematochezia. Computed tomography and endoscopy revealed findings compatible with gastrointestinal manifestations of IgAV. He was successfully treated by intravenous prednisolone and did not develop recurrence of IgAV during subsequent infliximab infusions.
我们报告了一例溃疡性结肠炎（UC）患者，该患者为 17 岁男性，正在接受英夫利昔单抗治疗，且有 IgA 血管炎（IgAV）家族史。在进行维持性英夫利昔单抗治疗时，他出现了可触及性紫癜、腹痛和便血。计算机断层扫描和内镜检查显示符合 IgAV 胃肠道表现的结果。他接受了静脉注射泼尼松龙治疗，并且在随后的英夫利昔单抗输注过程中没有出现 IgAV 复发。
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