Karmysheva V Ia, Pogodina V V
Vopr Virusol. 1987 May-Jun;32(3):342-7.
On the model of Syrian hamsters inoculated intracerebrally with 9 tick-borne encephalitis (TBE) virus strains varying in virulence, the specific involvement of the organs of the immune system (spleen and lymph nodes) was established and morphological features of the process described. The most severe destructive changes of these organs were found in the hamsters inoculated with highly virulent strains which appeared to be one of the factors leading to 100% death of the animals. In hamsters inoculated with strains of low virulence, the destructive changes in immunogenesis organs were less marked, but active migration and proliferative processes developed in them. The above-described differences in the involvement of the immune system organs should be taken into consideration in the interpretation of TBE pathogenesis and evaluation of the degree of virulence of the virus strains.
以叙利亚仓鼠为模型，脑内接种9种毒力不同的蜱传脑炎（TBE）病毒株，确定了免疫系统器官（脾脏和淋巴结）的特异性受累情况，并描述了该过程的形态学特征。在接种高毒力毒株的仓鼠中发现这些器官出现了最严重的破坏性变化，这似乎是导致动物100%死亡的因素之一。在接种低毒力毒株的仓鼠中，免疫发生器官的破坏性变化不太明显，但其中出现了活跃的迁移和增殖过程。在解释TBE发病机制和评估病毒株毒力程度时，应考虑上述免疫系统器官受累情况的差异。
