Tscheliessnigg K H, Berger A, Mischinger H J, Kraft-Kinz J
Universitätsklinik für Chirurgie Graz.
Wien Med Wochenschr. 1987 Aug 15;137(14-15):350-5.
With the development of this new galenic retard administration, we found in conclusion a significant longer action interval. A dose increase, similar to non retard administrations was on no account necessary. The new drug, Cimetidine retard, offers accordingly the opportunity of full utilization of the offered pharmacologic effective substance in combination with low dose administration and poor side effects.
随着这种新的长效制剂给药方式的发展,我们最终发现作用间隔明显延长。完全没有必要像非长效制剂给药那样增加剂量。因此,新药西咪替丁长效制剂提供了在低剂量给药且副作用小的情况下充分利用所提供药理活性物质的机会。