Department of Medicine, Queen Elizabeth Hospital, Hong Kong.
Department of Medicine and Geriatrics, Our Lady of Maryknoll Hospital, Hong Kong.
J Gastroenterol Hepatol. 2021 Feb;36(2):376-382. doi: 10.1111/jgh.15331. Epub 2020 Dec 2.
AmplifEYE is a mucosal exposure device mounted to the tip of colonoscope to improve polyp or adenoma detection. We aim to compare the adenoma detection rates (ADR) of AmplifEYE-assisted colonoscopy (AC) with standard colonoscopy (SC).
We performed a randomized controlled trial involving patients aged 50 to 79 who underwent AC or SC in two centers. Procedures were performed by five experienced colonoscopists.
Three hundred fifty-five patients were recruited, with 334 patients (170 AC and 164 SC) included into analysis. The ADR was numerically higher in AC (47.1%) versus SC (40.9%), P = 0.253. The polyp detection rate (PDR) in AC was 68.2% versus 54.3% in SC, P = 0.009, and serrated polyp detection rate (SDR) in AC was 37.6% versus 20.1% in SC, P < 0.001, both statistically significant higher in the study group. The mean cecal intubation time was shorter with AmplifEYE (8.0 min in AC vs 8.9 min in SC, P = 0.030), and there was no difference in pain score (3 in AC vs 4 in SC, P = 0.121).
AmplifEYE-assisted colonoscopy significantly improved the PDR and SDR, while the ADR was numerically higher in AC that did not reach statistical significance. Using the device resulted in shorter cecal intubation time and did not cause more pain.
AmplifEYE 是一种安装在结肠镜尖端的黏膜暴露装置，用于提高息肉或腺瘤的检出率。我们旨在比较 AmplifEYE 辅助结肠镜检查（AC）与标准结肠镜检查（SC）的腺瘤检出率（ADR）。
我们进行了一项随机对照试验，纳入了在两个中心接受 AC 或 SC 检查的年龄在 50 至 79 岁的患者。由五名经验丰富的结肠镜医师进行操作。
共招募了 355 名患者，其中 334 名患者（170 名 AC 和 164 名 SC）纳入分析。AC 的 ADR 数值上高于 SC（47.1%比 40.9%），但无统计学差异（P=0.253）。AC 的息肉检出率（PDR）为 68.2%，高于 SC 的 54.3%，差异有统计学意义（P=0.009），AC 的锯齿状息肉检出率（SDR）为 37.6%，高于 SC 的 20.1%，差异也有统计学意义（P<0.001）。使用 AmplifEYE 时，盲肠插管时间更短（AC 为 8.0 分钟，SC 为 8.9 分钟，P=0.030），但疼痛评分无差异（AC 为 3 分，SC 为 4 分，P=0.121）。
AmplifEYE 辅助结肠镜检查显著提高了 PDR 和 SDR，而 ADR 虽然在 AC 中更高，但未达到统计学意义。使用该装置可缩短盲肠插管时间，且不会增加疼痛。
