Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Melbourne, Australia.
Centre for Mental Health, Faculty of Health, Arts and Design, School of Health Sciences, Swinburne University, Melbourne, Australia; St Vincent's Mental Health, St Vincent's Hospital, VIC, Australia.
J Affect Disord. 2021 Jan 15;279:518-548. doi: 10.1016/j.jad.2020.10.038. Epub 2020 Oct 25.
Facial emotion processing abnormalities may be a trait feature of bipolar disorder (BD). These social cognitive impairments may be due to alterations in the neural processing of facial affective information in visual ("core"), and limbic and prefrontal ("extended") networks, however, the precise neurobiological mechanism(s) underlying these symptoms are unclear.
We conducted a systematic review to appraise the literature on the activity and connectivity of the facial emotion processing neural circuitry in BD. Two reviewers undertook a search of the electronic databases PubMed, Scopus and PsycINFO, to identify relevant literature published since inception up until September 2019. Study eligibility criteria included; BD participants, neuroimaging, and facial emotion processing tasks.
Out of an initial yield of 6121 articles, 66 were eligible for inclusion in this review. We identified differences in neural activity and connectivity within and between occipitotemporal, limbic, and prefrontal regions, in response to facial affective stimuli, in BD compared to healthy controls.
The methodologies used across studies varied considerably.
The findings from this review suggest abnormalities in both the activity and connectivity of facial emotion processing neural circuitry in BD. It is recommended that future research aims to further define the connectivity and spatiotemporal course of neural events within and between occipitotemporal, limbic, and prefrontal regions.
面部情绪处理异常可能是双相情感障碍（BD）的特征之一。这些社会认知障碍可能是由于视觉（“核心”）、边缘和前额叶（“扩展”）网络中面部情感信息的神经处理发生改变所致，但这些症状的确切神经生物学机制尚不清楚。
我们进行了一项系统评价，以评估 BD 患者面部情绪处理神经回路的活动和连接。两位审稿人在电子数据库 PubMed、Scopus 和 PsycINFO 中进行了搜索，以确定截至 2019 年 9 月发表的相关文献。研究入选标准包括：BD 参与者、神经影像学和面部情绪处理任务。
在最初的 6121 篇文章中，有 66 篇符合纳入本综述的标准。我们发现，与健康对照组相比，BD 患者在对面部情感刺激做出反应时，其枕颞、边缘和前额叶区域内和区域之间的神经活动和连接存在差异。
研究中使用的方法差异很大。
本综述的研究结果表明，BD 患者的面部情绪处理神经回路的活动和连接均存在异常。建议未来的研究旨在进一步确定枕颞、边缘和前额叶区域内和区域之间的神经连接和时空事件过程。
