Copenhagen Affective Disorder Research Centre (CADIC), Psychiatric Centre Copenhagen, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Department of Psychology, University of Copenhagen, Copenhagen, Denmark.
Bipolar Disord. 2019 Dec;21(8):686-719. doi: 10.1111/bdi.12834. Epub 2019 Oct 16.
Impairments in affective cognition are part of the neurocognitive profile and possible treatment targets in bipolar disorder (BD), but the findings are heterogeneous. The International Society of Bipolar Disorder (ISBD) Targeting Cognition Task Force conducted a systematic review to (i) identify the most consistent findings in affective cognition in BD, and (ii) provide suggestions for affective cognitive domains for future study and meta-analyses.
The review included original studies reporting behavioral measures of affective cognition in BD patients vs controls following the procedures of the Preferred Reporting Items for Systematic reviews and Meta-Analysis (PRISMA) statement. Searches were conducted on PubMed/MEDLINE, EMBASE, and PsychInfo from inception until November 2018.
A total of 106 articles were included (of which nine included data for several affective domains); 41 studies assessed emotional face processing; 23 studies investigated reactivity to emotional words and images; 3 investigated explicit emotion regulation; 17 assessed implicit emotion regulation; 31 assessed reward processing and affective decision making. In general, findings were inconsistent. The most consistent findings were trait-related difficulties in facial emotion recognition and implicit emotion regulation, and impairments in reward processing and affective decision making during mood episodes. Studies using eye-tracking and facial emotion analysis revealed subtle trait-related abnormalities in emotional reactivity.
The ISBD Task Force recommends facial expression recognition, implicit emotion regulation, and reward processing as domains for future research and meta-analyses. An important step to aid comparability between studies in the field would be to reach consensus on an affective cognition test battery for BD.
情感认知障碍是双相情感障碍（BD）神经认知特征的一部分，也是可能的治疗靶点，但研究结果存在异质性。国际双相情感障碍学会（ISBD）认知目标工作组进行了一项系统评价，以确定（i）BD 患者在情感认知方面最一致的发现，以及（ii）为未来的研究和荟萃分析提供情感认知领域的建议。
本综述包括了报道 BD 患者与对照组在行为测量方面的情感认知的原始研究，遵循系统评价和荟萃分析的首选报告项目（PRISMA）声明的程序。在 2018 年 11 月之前，在 PubMed/MEDLINE、EMBASE 和 PsychInfo 上进行了检索。
共纳入 106 篇文章（其中 9 篇文章包含了几个情感领域的数据）；41 项研究评估了情绪面孔处理；23 项研究调查了对情绪词和图像的反应性；3 项研究调查了显性行为情绪调节；17 项评估了隐性情绪调节；31 项评估了奖励处理和情感决策。总的来说，研究结果不一致。最一致的发现是与特质相关的面部表情识别困难和隐性情绪调节障碍，以及在情绪发作期间的奖励处理和情感决策受损。使用眼动追踪和面部情绪分析的研究揭示了情绪反应方面与特质相关的微妙异常。
ISBD 工作组建议将面部表情识别、隐性情绪调节和奖励处理作为未来研究和荟萃分析的领域。促进该领域研究之间可比性的一个重要步骤是就 BD 的情感认知测试组合达成共识。
