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[单次惊厥发作后大脑皮质中间神经元联系的结构与功能重组]

[Structural and functional reorganization of the interneuronal contacts of the cerebral cortex after a single convulsive paroxysm].

作者信息

Savchenko Iu N, Ereniev S I, Semchenko V V, Stepanov S S

出版信息

Zh Nevropatol Psikhiatr Im S S Korsakova. 1987;87(7):1040-3.

PMID:3314281
Abstract

Using the technique of contrasting the cerebral tissue with phosphotungstic acid, the authors studied the structural and functional status of interneuronal contacts of the molecular layer of the sensomotor cortex in the brain of Krushinsky-Molodkina rats following convulsive sound stimulation and the subsequent audiogenic convulsive paroxysm. Marked reduction in the general number of synapses 4 h after the attack was attended by transformation of some flat functionally mature contacts into concave ones, which reflects the activation of the synaptic pool. The relative levels of concave and flat mature contacts returned to the initial level 8 to 24 h later.

摘要

作者运用磷钨酸对脑组织进行对比的技术,研究了克鲁申斯基-莫洛迪纳大鼠在惊厥性声音刺激及随后的听源性惊厥发作后,其大脑感觉运动皮层分子层中间神经元接触的结构和功能状态。发作后4小时,突触总数显著减少,同时一些扁平的功能成熟接触转变为凹陷接触,这反映了突触池的激活。凹陷和扁平成熟接触的相对水平在8至24小时后恢复到初始水平。

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