Department of Chemistry, John Carroll University, University Heights, OH 44118, USA.
Int J Mol Sci. 2020 Oct 30;21(21):8113. doi: 10.3390/ijms21218113.
S-glutathionylation, the post-translational modification forming mixed disulfides between protein reactive thiols and glutathione, regulates redox-based signaling events in the cell and serves as a protective mechanism against oxidative damage. S-glutathionylation alters protein function, interactions, and localization across physiological processes, and its aberrant function is implicated in various human diseases. In this review, we discuss the current understanding of the molecular mechanisms of S-glutathionylation and describe the changing levels of expression of S-glutathionylation in the context of aging, cancer, cardiovascular, and liver diseases.
S-谷胱甘肽化，即蛋白质反应性巯基与谷胱甘肽之间形成混合二硫键的翻译后修饰，调节细胞内基于氧化还原的信号事件，并作为对抗氧化损伤的保护机制。S-谷胱甘肽化改变了蛋白质在生理过程中的功能、相互作用和定位，其异常功能与多种人类疾病有关。在这篇综述中，我们讨论了 S-谷胱甘肽化的分子机制的现有理解，并描述了 S-谷胱甘肽化在衰老、癌症、心血管和肝脏疾病背景下表达水平的变化。
