卡培他滨联合贝伐珠单抗治疗乙状结肠癌心脏转移：病例报告及文献复习。
Capecitabine Plus Bevacizumab for Cardiac Metastasis of Sigmoid Colon Cancer: Case Report and Literature Review.
机构信息
Department of Gastroenterological Surgery, Hiroshima Prefectural Hospital, Hiroshima, Japan.
Department of Gastroenterological Surgery, Hiroshima Prefectural Hospital, Hiroshima, Japan
出版信息
In Vivo. 2020 Nov-Dec;34(6):3413-3419. doi: 10.21873/invivo.12180.
BACKGROUND/AIM: Right ventricular cardiac metastasis from colorectal cancer (CRC) is rare and clinically silent. There is no standardised treatment. To date, only twelve cases have been reported in the literature. This is a case report and literature review of right ventricular cardiac metastasis from CRC.
CASE REPORT
A 75-year-old woman with a history of CRC treated with sigmoidectomy followed by liver and lung metastasectomy presented with a right ventricle tumour. Biopsy showed metastatic adenocarcinoma not suitable for resection because multiple lung metastases coexisted. The metastases were controlled for a prolonged duration by chemotherapy with capecitabine plus bevacizumab. According to the review of 13 cases, the median age of metastatic CRC that involves the right ventricle is 71 years and the primary site is half the colon and rectum. Half of cases have non-cardiac metastases at cardiac metastasis diagnosis. Chemotherapy is more suitable than resection in cases with metastases other than heart because resection of the right ventricle has a high risk.
CONCLUSION
Cardiac right ventricular metastasis from CRC can be controlled by capecitabine plus bevacizumab.
背景/目的：结直肠癌（CRC）的右心室心脏转移较为罕见且无临床症状。目前尚无标准治疗方法。迄今为止，文献中仅报道了 12 例。这是一例结直肠癌右心室心脏转移的病例报告和文献复习。
病例报告
一名 75 岁女性，患有 CRC，接受了乙状结肠切除术，随后进行了肝和肺转移切除术，出现了右心室肿瘤。活检显示转移性腺癌不适合切除，因为同时存在多个肺转移。卡培他滨联合贝伐珠单抗化疗使转移得到了长时间的控制。根据对 13 例病例的回顾，涉及右心室的转移性 CRC 的中位年龄为 71 岁，原发部位为结肠和直肠的一半。一半的病例在心脏转移诊断时存在非心脏转移。对于非心脏转移的病例，化疗比切除术更合适，因为右心室切除术风险较高。
结论
卡培他滨联合贝伐珠单抗可控制结直肠癌的右心室心脏转移。
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