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深部脑刺激治疗难治性强迫症(OCD):新兴还是成熟的治疗方法?

Deep brain stimulation for refractory obsessive-compulsive disorder (OCD): emerging or established therapy?

机构信息

Department of Neurosurgery, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.

Department of Clinical Neuroscience, Umeå University, Umeå, Sweden.

出版信息

Mol Psychiatry. 2021 Jan;26(1):60-65. doi: 10.1038/s41380-020-00933-x. Epub 2020 Nov 3.

Abstract

A consensus has yet to emerge whether deep brain stimulation (DBS) for treatment-refractory obsessive-compulsive disorder (OCD) can be considered an established therapy. In 2014, the World Society for Stereotactic and Functional Neurosurgery (WSSFN) published consensus guidelines stating that a therapy becomes established when "at least two blinded randomized controlled clinical trials from two different groups of researchers are published, both reporting an acceptable risk-benefit ratio, at least comparable with other existing therapies. The clinical trials should be on the same brain area for the same psychiatric indication." The authors have now compiled the available evidence to make a clear statement on whether DBS for OCD is established therapy. Two blinded randomized controlled trials have been published, one with level I evidence (Yale-Brown Obsessive Compulsive Scale (Y-BOCS) score improved 37% during stimulation on), the other with level II evidence (25% improvement). A clinical cohort study (N = 70) showed 40% Y-BOCS score improvement during DBS, and a prospective international multi-center study 42% improvement (N = 30). The WSSFN states that electrical stimulation for otherwise treatment refractory OCD using a multipolar electrode implanted in the ventral anterior capsule region (including bed nucleus of stria terminalis and nucleus accumbens) remains investigational. It represents an emerging, but not yet established therapy. A multidisciplinary team involving psychiatrists and neurosurgeons is a prerequisite for such therapy, and the future of surgical treatment of psychiatric patients remains in the realm of the psychiatrist.

摘要

对于治疗抵抗性强迫症(OCD)是否可以考虑采用深部脑刺激(DBS)治疗,目前尚未达成共识。2014 年,世界立体定向和功能神经外科学会(WSSFN)发布了共识指南,指出当“至少有两个来自不同研究小组的盲法随机对照临床试验发表,均报告可接受的风险-效益比,至少与其他现有疗法相当”时,一种疗法就可以被认为是成熟的。这些临床试验应该针对同一脑部区域和同一精神疾病适应证。作者现在汇集了现有证据,以明确说明 OCD 的 DBS 是否是成熟的治疗方法。已经发表了两项盲法随机对照试验,其中一项具有 I 级证据(耶鲁-布朗强迫症量表(Y-BOCS)评分在刺激期间改善了 37%),另一项具有 II 级证据(改善了 25%)。一项临床队列研究(N=70)显示 DBS 期间 Y-BOCS 评分改善了 40%,一项前瞻性国际多中心研究显示改善了 42%(N=30)。WSSFN 指出,使用植入腹侧前囊区域(包括终纹床核和伏隔核)的多极电极对其他治疗抵抗性 OCD 进行电刺激仍处于研究阶段。它代表了一种新兴但尚未成熟的治疗方法。一个由精神科医生和神经外科医生组成的多学科团队是这种治疗方法的前提,精神科患者的手术治疗的未来仍然在精神科医生的领域内。

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