双硫仑依从性的化学监测：一项针对酒精依赖门诊患者的研究。

Chemical monitoring of disulfiram compliance: a study of alcoholic outpatients.

作者信息

Kofoed L L

机构信息

Psychiatry Service, Portland Veterans Administration Medical Center, Oregon.

出版信息

Alcohol Clin Exp Res. 1987 Oct;11(5):481-5. doi: 10.1111/j.1530-0277.1987.tb01928.x.

DOI:10.1111/j.1530-0277.1987.tb01928.x

PMID:3314565

Abstract

Poor compliance with disulfiram (Antabuse) therapy may reduce its efficacy in the treatment of alcoholism. This study was designed to examine two questions: (a) Could use of a chemical test for disulfiram ingestion be used clinically to improve disulfiram compliance and if so, (b) could improved disulfiram compliance contribute to improved compliance with other aspects of treatment? The results suggest that disulfiram compliance rates can be increased by clinical use of chemical monitoring data; however in this sample increased compliance with disulfiram did not correlate with improvements in other aspects of treatment compliance.

摘要

对双硫仑（戒酒硫）治疗的依从性差可能会降低其在治疗酒精中毒方面的疗效。本研究旨在探讨两个问题：（a）使用化学检测来确定是否摄入双硫仑能否在临床上用于提高双硫仑治疗的依从性，如果可以的话，（b）提高双硫仑治疗的依从性是否有助于改善对治疗其他方面的依从性？结果表明，通过临床使用化学监测数据可以提高双硫仑治疗的依从率；然而，在这个样本中，双硫仑治疗依从性的提高与治疗依从性其他方面的改善并无关联。