Department of Pharmacy, Liaocheng People's Hospital, Liaocheng, Shandong, People's Republic of China.
Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Tongji School of Pharmaceutical Sciences, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
Nat Prod Res. 2022 Feb;36(4):891-895. doi: 10.1080/14786419.2020.1843033. Epub 2020 Nov 4.
A new phenolic glycoside, chinenside A (), and a new megastigmane glycoside, chinenionside A (), together with twelve known compounds (), were isolated from the roots of . Their structures were deduced on the basis of extensive spectroscopic analyses and comparison with data reported in the literature. The anti-inflammatory activity in vitro of all 13 phenolic glycosides was evaluated against lipopolysaccharide-induced mouse macrophage RAW264.7 cells. The compounds , , and potentially inhibited the productions of nitric oxide (NO), prostaglandin (PEG), tumor necrosis factor alpha (TNF-α), interleukin 1 beta (IL-1β) and interleukin 6 (IL-6). Compound (50 μM) showed stronger anti-inflammatory activity than Triptolide (TPL, 20 nm).
从秦艽的根部分离得到了一个新的酚糖苷，秦艽苷 A ()，和一个新的 megastigmane 糖苷，秦艽苷 A ()，以及十二个已知化合物 ()。根据广泛的光谱分析和与文献报道的数据比较，推断出它们的结构。所有 13 个酚糖苷的抗炎活性在体外用脂多糖诱导的小鼠巨噬细胞 RAW264.7 细胞进行评估。化合物 、 和 可能抑制一氧化氮（NO）、前列腺素（PEG）、肿瘤坏死因子 alpha（TNF-α）、白细胞介素 1 beta（IL-1β）和白细胞介素 6（IL-6）的产生。化合物 （50μM）显示出比雷公藤内酯甲（TPL，20nm）更强的抗炎活性。
