School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, China.
State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center of Biotherapy, Chengdu, China.
Nat Prod Res. 2021 May;35(9):1452-1458. doi: 10.1080/14786419.2019.1655020. Epub 2019 Aug 27.
Three new phenolic glycosides, intermedia A-C (-), one new acyclic alcohol glycoside, intermedia D (), together with 3 known glycosides (-), were isolated from the dried roots of C. A. Meyer. Their structures were established by means of extensive spectroscopic analysis (HRESIMS, NMR). Compound have a rare benzo[1,5]dioxepine skeleton. The bioassay results showed that compound exhibited inhibitory activity against proinflammatory cytokines nitric oxide (NO) secretion in LPS-activated RAW264.7 cells with an IC value of 85.76 ± 1.36 μM.
从秦艽的干燥根部分离得到三个新的酚糖苷，中间体 A-C(-)，一个新的无环醇糖苷，中间体 D()，以及三个已知的糖苷(-)。它们的结构通过广泛的光谱分析（HRESIMS，NMR）确定。化合物具有罕见的苯并[1,5]二氧杂环庚烷骨架。生物测定结果表明，化合物对 LPS 激活的 RAW264.7 细胞中的促炎细胞因子一氧化氮（NO）分泌表现出抑制活性，IC 值为 85.76±1.36μM。
