Spanou Ioanna, Christidi Foteini, Liakakis Georgios, Rizonaki Konstantina, Bougea Anastasia, Anagnostou Evangelos, Kararizou Evangelia
National and Kapodistrian University of Athens, Medical School, Aeginition Hospital, Athens, Greece.
Arq Neuropsiquiatr. 2020 Nov;78(11):695-699. doi: 10.1590/0004-282X20200070.
Primary headaches, and particularly migraine and tension-type headache (TTH) as well as hypothyroidism are common medical conditions. To date, numerous studies have suggested a possible bidirectional relationship between migraine and hypothyroidism, although certain studies had contradictory results.
To investigate whether there is any association between primary headache subtypes and thyroid disorders.
A retrospective study of consecutive patients aged ≥18 years referred to the Headache Outpatient Clinic of Aeginition Hospital and diagnosed with primary headache and any thyroid disorder.
Out of 427 patients (males/females=76/351), 253 (59.3%) were diagnosed with migraine without aura, 53 (12.4%) with TTH, 49 (11.5%) with migraine with aura, 29 (6.8%) with medication-overuse headache, 23 (5.4%) with mixed-type headache (migraine with/without aura and TTH), nine (2.1%) with cluster headache, and 11 (2.6%) with other types of primary headaches. The prevalence of any type of thyroid disorder was 20.8% (89/427 patients). In the total sample, 27 patients (6.3%) reported hypothyroidism, 18 (4.2%) unspecified thyroidopathy, 14 (3.3%) thyroid nodules, 12 (2.8%) Hashimoto thyroiditis, 12 (2.8%) thyroidectomy, three (0.7%) thyroid goiter, and three (0.7%) hyperthyroidism. Further statistical analysis between categorical variables did not reveal any significant association between headache subtypes and thyroid dysfunction.
No specific association was found between primary headache subtypes and specific thyroid disorder. However, a high prevalence of thyroid dysfunction in general and specifically hypothyroidism was demonstrated among patients with primary headaches, which lays the foundation for further clarification in prospective longitudinal studies.
原发性头痛，尤其是偏头痛和紧张型头痛（TTH）以及甲状腺功能减退是常见的病症。迄今为止，众多研究表明偏头痛与甲状腺功能减退之间可能存在双向关系，尽管某些研究结果相互矛盾。
调查原发性头痛亚型与甲状腺疾病之间是否存在关联。
对连续转诊至阿伊尼蒂翁医院头痛门诊且诊断为原发性头痛和任何甲状腺疾病的≥18岁患者进行回顾性研究。
在427例患者（男性/女性=76/351）中，253例（59.3%）被诊断为无先兆偏头痛，53例（12.4%）为紧张型头痛，49例（11.5%）为有先兆偏头痛，29例（6.8%）为药物过量使用性头痛，23例（5.4%）为混合型头痛（有/无先兆偏头痛和紧张型头痛），9例（2.1%）为丛集性头痛，11例（2.6%）为其他类型的原发性头痛。任何类型甲状腺疾病的患病率为20.8%（89/427例患者）。在总样本中，27例患者（6.3%）报告有甲状腺功能减退，18例（4.2%）为未明确的甲状腺疾病，14例（3.3%）有甲状腺结节，12例（2.8%）为桥本甲状腺炎，12例（2.8%）有甲状腺切除术史，3例（0.7%）有甲状腺肿，3例（0.7%）有甲状腺功能亢进。分类变量之间的进一步统计分析未显示头痛亚型与甲状腺功能障碍之间存在任何显著关联。
未发现原发性头痛亚型与特定甲状腺疾病之间存在特定关联。然而，原发性头痛患者中总体甲状腺功能障碍，尤其是甲状腺功能减退的患病率较高，这为前瞻性纵向研究的进一步阐明奠定了基础。
