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[抗生链霉菌RIA - 594(39)的细胞壁多糖组成,该菌株为抗生素竹桃霉素的产生菌]

[Polysaccharide composition of the cell wall of Streptomyces antibioticus RIA-594(39), a producer of the antibiotic oleandomycin].

作者信息

Zaretskaia M Sh, Polin A N

出版信息

Antibiot Med Biotekhnol. 1987 Jul;32(7):529-33.

PMID:3314690
Abstract

The main polysaccharide components of the cell wall in S. antibioticus RIA-594 (39) i.e. peptidoglycan, teichoic acid and polysaccharide were studied. Peptidoglycan consists of the polysaccharide fraction containing equimolar quantities of N-acetylglucosamine and muramic acid and the peptide subunits including alanine, glutamic and L,L-diaminopimelic acids and glycine at a ratio of 1.4:0.9:1:0.9. It is characteristic that certain peptide subunits of the streptomycete contain no alanine. A polysaccharide differing from glycerol teichoic acid and containing galactose and N-acetylglucosamine was isolated from the cell wall. During the streptomycete development the quantity of peptidoglycan remained constant, the quantity of teichoic acid lowered and the quantity of polysaccharide increased. Correlation between the presence of aminosugars in the composition of teichoic acid and polysaccharide specific of the streptomycete cell wall and the presence of aminosugars in the structure of oleandomycin was shown. This is probably connected with characteristic features of the organism physiology.

摘要

对抗生链霉菌RIA - 594(39)细胞壁的主要多糖成分,即肽聚糖、磷壁酸和多糖进行了研究。肽聚糖由含有等摩尔量的N - 乙酰葡糖胺和胞壁酸的多糖部分以及包括丙氨酸、谷氨酸、L,L - 二氨基庚二酸和甘氨酸且比例为1.4:0.9:1:0.9的肽亚基组成。链霉菌的某些肽亚基不含丙氨酸是其特征。从细胞壁中分离出一种不同于甘油磷壁酸且含有半乳糖和N - 乙酰葡糖胺的多糖。在链霉菌发育过程中,肽聚糖的量保持恒定,磷壁酸的量降低,多糖的量增加。结果表明,磷壁酸组成中的氨基糖以及链霉菌细胞壁特有的多糖与竹桃霉素结构中的氨基糖的存在之间存在相关性。这可能与该生物体生理的特征有关。

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