Marone C, Flury W, Frey F, Keller H
Schweiz Med Wochenschr. 1977 Jul 30;107(30):1066-72.
Within three patient groups (1. advanced renal failure, 2. patients under chronic hemodialysis, 3. patients with renal transplants) 16 serum proteins were determined immunochemically employing MANCINIS method. The group mean values for each protein were compared, and the statistical significance of intergroup differences was examined. The most noteworthy results were the following: a distinct increase in prealbumin in all groups, least marked in the dialyzed patients; frequent elevation of alpha2-macroglobulin in the patients with transplanted kidney, but not in the other two groups; a significant increase in beta2-glycoprotein in all groups. Other changes affected several components of the acute phase reactants which were, in part, markedly elevated. On the other hand, alpha1-antitrypsin and transferrin remained largely within the normal range. Possible mechanisms accounting for some of these changes are discussed.
在三组患者（1. 晚期肾衰竭患者；2. 慢性血液透析患者；3. 肾移植患者）中，采用曼西尼斯方法免疫化学测定了16种血清蛋白。比较了每组每种蛋白的组均值，并检验了组间差异的统计学显著性。最值得注意的结果如下：所有组中前白蛋白均有明显升高，在透析患者中升高最不明显；肾移植患者中α2-巨球蛋白经常升高，但在其他两组中未出现这种情况；所有组中β2-糖蛋白均显著增加。其他变化影响了急性期反应物的几个成分，其中一些成分明显升高。另一方面，α1-抗胰蛋白酶和转铁蛋白大多仍在正常范围内。文中讨论了解释其中一些变化的可能机制。
