Zazgornik J, Kopsa H, Schmidt P, Pils P, Balcke P, Hysek H, Deutsch E
J Clin Chem Clin Biochem. 1980 Apr;18(4):241-4.
alpha 1-Antitrypsin in serum was determined by radial immunodiffusion in 30 healthy persons, 18 dialyzed patients and 11 renal transplant recipients with an observation time up to 24 months after surgery. There was no significant difference in serum alpha 1-antitrypsin concentrations in dialyzed patients when compared to the controls (2570 +/- 570 and 2280 +/- 450 mg/l respectively). alpha 1-Antitrypsin concentration increased significantly from the first day after successful renal transplantation, then decreased again 10 days thereafter. Long term follow up controls 3, 6, 12, 18 and 24 months respectively after surgery--with a good renal transplant function--revealed values within the normal range. An acute rejection episode of the transplant was connected with a significant increase of alpha 1-antitrypsin concentration in the serum. Determination of alpha 1-antitrypsin level in serum can be useful in the diagnosis and prognosis of acute renal transplant rejection.
采用放射免疫扩散法测定了30名健康人、18名透析患者和11名肾移植受者血清中的α1-抗胰蛋白酶，对肾移植受者术后长达24个月进行了观察。与对照组相比，透析患者血清α1-抗胰蛋白酶浓度无显著差异（分别为2570±570和2280±450mg/L）。肾移植成功后第一天，α1-抗胰蛋白酶浓度显著升高，之后10天再次下降。术后分别在3、6、12、18和24个月对肾移植功能良好的患者进行长期随访，结果显示其值在正常范围内。移植的急性排斥反应与血清中α1-抗胰蛋白酶浓度显著升高有关。测定血清α1-抗胰蛋白酶水平有助于急性肾移植排斥反应的诊断和预后判断。
