靶向丙酮酸激酶 PEPs 可增强胰岛素分泌并改善葡萄糖稳态。
Targeting Pyruvate Kinase PEPs Up Insulin Secretion and Improves Glucose Homeostasis.
机构信息
Boston University School of Medicine, Obesity Research Center, 650 Albany Street, Boston, MA 02118, USA.
出版信息
Cell Metab. 2020 Nov 3;32(5):693-694. doi: 10.1016/j.cmet.2020.10.008.
The consensus model of glucose-stimulated insulin secretion (GSIS) holds that ATP generation by oxidative phosphorylation directly regulates K channel activity and thus insulin granule release, a concept inconsistent with bioenergetic principles. Here, Lewandowski et al. (2020) and Abulizi et al. (2020) report that regulation of GSIS is much more complex as different sources of ATP generation are essential to control this process, which can be targeted in vivo and additionally modulate hepatic glucose production. These findings establish an important new conceptual framework of GSIS and in vivo glucose homeostasis.
葡萄糖刺激的胰岛素分泌 (GSIS) 的共识模型认为，氧化磷酸化产生的 ATP 直接调节 K 通道活性，从而调节胰岛素颗粒的释放，这一概念与生物能量学原理不一致。在这里，Lewandowski 等人（2020 年）和 Abulizi 等人（2020 年）报告称，GSIS 的调节要复杂得多，因为不同的 ATP 产生来源对于控制这一过程是必不可少的，这一过程可以在体内靶向，并额外调节肝脏葡萄糖的产生。这些发现为 GSIS 和体内葡萄糖稳态建立了一个重要的新概念框架。
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