Department of Geriatric Psychiatry, Arkin Mental Health Care, Amsterdam, the Netherlands.
Department of Psychiatry, Arkin Mental Health Care, Amsterdam, the Netherlands.
Aging Ment Health. 2021 Dec;25(12):2246-2254. doi: 10.1080/13607863.2020.1843001. Epub 2020 Nov 5.
Loneliness and social isolation have both been found to be associated with increased mortality in previous studies. One potential underlying mechanism is via the hypothalamic-pituitary-adrenal axis.
This study aimed to examine the association between social network size and cortisol, to analyze the associations between both loneliness and social network size and mortality, and to examine to what extent the association between network size and/or loneliness and mortality is mediated by cortisol.
The study group consisted of 443 depressed and non-depressed participants of the Netherlands Study of Depression in the Elderly (NESDO). Cross-sectional analysis of the association between social network size and cortisol measures was followed by a survival analysis of the associations between both social network size and loneliness and mortality.
There were no significant associations between social network size and cortisol measures. Loneliness and small social network size were not associated with mortality. Age and partner status were more important predictors of mortality.
As people grow older the variety of factors that influence mortality risk increases, diminishing the effect of a single factor. Prevention of early morbidity and mortality in older adults should be tailored to specific needs and risks, instead of aiming at one specific factor.
在之前的研究中，孤独感和社会隔离都与死亡率的增加有关。一个潜在的潜在机制是通过下丘脑-垂体-肾上腺轴。
本研究旨在探讨社会网络规模与皮质醇之间的关系，分析孤独感和社会网络规模与死亡率之间的关系，并探讨网络规模和/或孤独感与死亡率之间的关系在多大程度上受皮质醇调节。
该研究组由荷兰老年抑郁症研究（NESDO）的 443 名抑郁和非抑郁参与者组成。对社会网络规模与皮质醇测量之间的关系进行横断面分析，然后对社会网络规模和孤独感与死亡率之间的关系进行生存分析。
社会网络规模与皮质醇测量之间没有显著关系。孤独感和小社交网络规模与死亡率无关。年龄和伴侣状况是死亡率的更重要预测因素。
随着年龄的增长，影响死亡率风险的因素种类增加，单一因素的影响减弱。预防老年人的早期发病和死亡应针对特定需求和风险进行调整，而不是针对特定因素。
