Science Centre Health and Technology, University of South-Eastern Norway, Grønland 53, 3045, Drammen, Norway.
Faculty of Medicine, Department of Pediatrics, University of Maribor, Taborska ulica 8, 2000, Maribor, Slovenia.
Health Qual Life Outcomes. 2020 Nov 4;18(1):356. doi: 10.1186/s12955-020-01612-9.
Measurements of health-related quality of life (HRQoL) among celiac disease patients using a validated questionnaire have been lacking in Slovenia. This study aims to measure HRQoL in celiac disease (CD) patients using EQ-5D internationally validated questionnaire and comparing it to the HRQoL of the general population.
In this cross sectional analysis all of the approximately 2000 members of the Slovenian Celiac Society were invited to take part. We used a 3 step approach for recruitment and data collection. HRQoL was evaluated through the EuroQoL EQ-5D-5L instrument (Slovenian version) and analysed using the ordinal logistic regression.
Out of 321 patients who gave their consent, 247 celiac patients were included in the study (77%). 68% of the participants were female and 53% of them lived in an urban setting. Most patients originated from North-East Slovenia, whereas approximately 30% of patients came from other Slovenian regions. The EQ-5D respondents' self-reported health status at the time of the study show that most patients have slight or no problems when living with CD. The duration of the gluten-free diet, academic education and rare (< 1 × year) doctor visits affect EQ-5D in a positive way. On the other hand, higher age and chronic rheumatic disease were negatively associated with EQ-5D also when compared to the general population.
This is the first Slovenian study to measure the HRQoL of Slovenian CD patients, using an internationally validated questionnaire. The results of our study show that HRQoL is slightly impaired among Slovenian patients with CD. Clinical characteristics are better determinants of their HRQoL than socio-demographic factors. Greater awareness of the impact of CD on patients' HRQoL would improve the holistic management of CD patients.
在斯洛文尼亚，缺乏使用经过验证的问卷测量乳糜泻患者健康相关生活质量（HRQoL）的研究。本研究旨在使用国际上经过验证的 EQ-5D 问卷测量乳糜泻（CD）患者的 HRQoL，并将其与一般人群的 HRQoL 进行比较。
在这项横断面分析中，邀请了大约 2000 名斯洛文尼亚乳糜泻协会的成员参加。我们采用了 3 步招募和数据收集方法。使用欧洲五维健康量表（EQ-5D-5L）评估 HRQoL，并使用有序逻辑回归进行分析。
在同意参加的 321 名患者中，有 247 名乳糜泻患者（77%）被纳入研究。68%的参与者为女性，53%居住在城市。大多数患者来自斯洛文尼亚东北部，而大约 30%的患者来自其他斯洛文尼亚地区。在研究时，EQ-5D 受访者自我报告的健康状况表明，大多数患者在患有 CD 时仅有轻微或无问题。无麸质饮食的持续时间、学历和较少（<1 次/年）就诊会对 EQ-5D 产生积极影响。另一方面，与一般人群相比，较高的年龄和慢性风湿性疾病也与 EQ-5D 呈负相关。
这是第一项使用国际上经过验证的问卷测量斯洛文尼亚 CD 患者 HRQoL 的研究。我们的研究结果表明，斯洛文尼亚 CD 患者的 HRQoL 略有受损。临床特征比社会人口因素更好地决定了他们的 HRQoL。提高对 CD 对患者 HRQoL 影响的认识将改善 CD 患者的整体管理。
