Pham Kay T, Balaguru Duraisamy, Tammisetti Varaha S, Guevara Carlos J, Rasmussen John C, Zvavanjanja Rodrick C, Hanfland Robert, Sevick-Muraca Eva M, Aldrich Melissa B
Center for Molecular Imaging, The Brown Foundation Institute of Molecular Medicine, UT Health, 1825 Pressler St, Houston, TX, 77030, USA.
Department of Pediatric Cardiology, McGovern Medical School At UTHealth, 6431 Fannin St, Houston, TX, 77030, USA.
Eur J Med Res. 2020 Nov 4;25(1):55. doi: 10.1186/s40001-020-00455-w.
Chylothorax is a rare complication of pediatric cardiac operations that occurs more frequently in children with Noonan syndrome, a genetic disorder associated with cardiac defects and lymphatic anomalies.
We report a case of postoperative chylothorax in a 6-month-old infant with Noonan syndrome where multimodality lymphatic imaging guided management was followed. Drainage patterns of the lymphatic capillaries in the lower and upper extremities were visualized during near-infrared fluorescence lymphatic imaging (NIRFLI). Dynamic magnetic resonance lymphangiography (MRL) further identified the site of leakage in the thoracic duct and subsequently guided surgical intervention.
Application of multimodality imaging allows for greater individualization of treatment and should be considered in patients with complex cases such as those with syndromes associated with a higher incidence of chylothorax. IRB Number: HSC-MS-13-0754, December 10, 2013.
乳糜胸是小儿心脏手术罕见的并发症，在努南综合征患儿中更常见，努南综合征是一种与心脏缺陷和淋巴异常相关的遗传性疾病。
我们报告一例6个月大患有努南综合征的婴儿术后乳糜胸病例，该病例采用多模态淋巴成像指导治疗。在近红外荧光淋巴成像（NIRFLI）过程中观察到了下肢和上肢淋巴管的引流模式。动态磁共振淋巴管造影（MRL）进一步确定了胸导管的漏出部位，并随后指导了手术干预。
多模态成像的应用使治疗更具个体化，对于乳糜胸发生率较高的综合征等复杂病例的患者应考虑使用。机构审查委员会编号：HSC-MS-13-0754，2013年12月10日。
