Preziosi Alessandra, Paraboschi Irene, Giuliani Stefano
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico di Milano, 20122 Milano, Italy.
Cancer Section, Developmental Biology and Cancer Programme, UCL, Great Ormond Street Institute of Child Health, London WC1N 1EH, UK.
Children (Basel). 2023 Apr 5;10(4):689. doi: 10.3390/children10040689.
Fluorescence-guided surgery (FGS) is used in many pediatric subspecialties but there are currently no standard guidelines or outcome data. We aimed to assess the current status of FGS in pediatrics using the Idea, Development, Exploration, Assessment, and Long-term study (IDEAL) framework. Clinical papers on FGS in children published from January 2000 to December 2022 were systematically reviewed. The stage of research development was measured considering seven fields of application: biliary tree imaging, vascular perfusion for gastrointestinal procedures, lymphatic flow imaging, tumor resection, urogenital surgery, plastic surgery, and miscellaneous procedures. Fifty-nine articles were selected. For each field of application, the overall IDEAL stage was determined to be 2a for biliary tree imaging (10 publications, 102 cases), 1 for vascular perfusion for gastrointestinal procedures (8 publications, 28 cases), 1 for lymphatic flow imaging (12 publications, 33 cases), 2a for tumor resection (20 publications, 238 cases), 2a for urogenital surgery (9 publications, 197 cases), and 1-2a for plastic surgery (4 publications, 26 cases). One report did not belong to any categories. FGS in children is still in an early phase of adoption and development. We recommend using the IDEAL framework as a guide and suggest developing multicenter studies to define the standard guidelines, effectiveness, and outcomes.
荧光引导手术（FGS）在许多儿科亚专业中都有应用，但目前尚无标准指南或疗效数据。我们旨在使用构思、开发、探索、评估和长期研究（IDEAL）框架来评估儿科FGS的现状。对2000年1月至2022年12月发表的关于儿童FGS的临床论文进行了系统综述。从胆道成像、胃肠道手术的血管灌注、淋巴流成像、肿瘤切除、泌尿生殖外科手术、整形手术和其他手术这七个应用领域来衡量研究发展阶段。共筛选出59篇文章。对于每个应用领域，胆道成像的总体IDEAL阶段确定为2a（10篇出版物，102例），胃肠道手术的血管灌注为1（8篇出版物，28例），淋巴流成像为1（12篇出版物，33例），肿瘤切除为2a（20篇出版物，238例），泌尿生殖外科手术为2a（9篇出版物，197例），整形手术为1 - 2a（4篇出版物，26例）。有一份报告不属于任何类别。儿童FGS仍处于应用和发展的早期阶段。我们建议以IDEAL框架为指导，并建议开展多中心研究以确定标准指南、有效性和疗效。
