Laboratory of Systems Biology and Genetics, Institute of Bioengineering, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland.
Laboratory of Systems Biology and Genetics, Institute of Bioengineering, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland; Swiss Institute of Bioinformatics, CH-1015 Lausanne, Switzerland.
Trends Cell Biol. 2020 Dec;30(12):937-950. doi: 10.1016/j.tcb.2020.09.007. Epub 2020 Oct 23.
White adipose tissue (WAT) is a cellularly heterogeneous endocrine organ that not only serves as an energy reservoir, but also actively participates in metabolic homeostasis. Among the main constituents of adipose tissue are adipocytes, which arise from adipose stem and progenitor cells (ASPCs). While it is well known that these ASPCs reside in the stromal vascular fraction (SVF) of adipose tissue, their molecular heterogeneity and functional diversity is still poorly understood. Driven by the resolving power of single-cell transcriptomics, several recent studies provided new insights into the cellular complexity of ASPCs among different mammalian fat depots. In this review, we present current knowledge on ASPCs, their population structure, hierarchy, fat depot-specific nature, function, and regulatory mechanisms, and discuss not only the similarities, but also the differences between mouse and human ASPC biology.
白色脂肪组织（WAT）是一种细胞异质性的内分泌器官，不仅作为能量储存库，还积极参与代谢稳态。脂肪组织的主要成分之一是脂肪细胞，它起源于脂肪干细胞和祖细胞（ASPCs）。虽然众所周知，这些 ASPC 存在于脂肪组织的基质血管部分（SVF）中，但它们的分子异质性和功能多样性仍知之甚少。单细胞转录组学的解析力推动了几个最近的研究，这些研究为不同哺乳动物脂肪组织中 ASPC 的细胞复杂性提供了新的见解。在这篇综述中，我们介绍了 ASPC 的现有知识，包括其群体结构、层次结构、脂肪组织特异性、功能和调节机制，并不仅讨论了小鼠和人类 ASPC 生物学之间的相似性，还讨论了它们之间的差异。
