Myers R K, Arp L H
Department of Veterinary Pathology, College of Veterinary Medicine, Iowa State University, Ames 50011.
Avian Dis. 1987 Jul-Sep;31(3):622-8.
Two groups of young turkeys, one passively immunized with homologous hyperimmune serum and the other unimmunized but receiving normal turkey serum, were aerosolized with Escherichia coli. Clearance of bacteria from lung and gross and microscopic lung and air-sac lesions were determined after necropsy at timed intervals. The group mean bacterial count in lungs of passively immunized turkeys was significantly less than the mean count in unimmunized turkeys. Lung lesions were generally similar in both groups and were focused in lymphoid nodules, at the junction of primary and secondary bronchi, and at the ostia to the air sacs. Unimmunized birds developed grossly evident purulent airsacculitis by 72 hours after aerosol exposure, whereas passively immunized birds did not.
将两组小火鸡，一组用同源超免疫血清进行被动免疫，另一组未免疫但接受正常火鸡血清，用大肠杆菌进行雾化处理。在不同时间间隔进行尸检后，测定肺部细菌清除情况以及肺部和气囊的大体和微观病变。被动免疫火鸡肺部的细菌平均计数显著低于未免疫火鸡的平均计数。两组的肺部病变总体相似，集中在淋巴小结、初级和次级支气管交界处以及气囊开口处。未免疫的鸟类在雾化暴露后72小时出现明显的脓性气囊炎，而被动免疫的鸟类则未出现。
