Division of Pediatric Hematology and Oncology, Department of Pediatrics, Pennsylvania State University College of Medicine, Hershey, PA, USA.
Leukemia. 2021 Feb;35(2):360-376. doi: 10.1038/s41375-020-01066-4. Epub 2020 Nov 4.
RNA-binding proteins (RBPs) play a crucial role in cellular physiology by regulating RNA processing, translation, and turnover. In neoplasms, RBP support of cancer-relevant expression of alternatively spliced, modified, and stabilized mRNA transcripts is essential to self-renewal, proliferation, and adaptation to stress. In this review, we assess the impact of key families of RBPs in leukemogenesis, review progress in targeting those proteins with small molecules, and discuss how multilevel composition of posttranscriptional regulation of gene expression could be used for potential therapies in acute and chronic leukemia.
RNA 结合蛋白 (RBPs) 通过调节 RNA 加工、翻译和周转，在细胞生理学中发挥着至关重要的作用。在肿瘤中，RBP 支持与癌症相关的可变剪接、修饰和稳定的 mRNA 转录本的表达，对于自我更新、增殖和适应应激至关重要。在这篇综述中，我们评估了关键 RBP 家族在白血病发生中的作用，回顾了用小分子靶向这些蛋白的进展，并讨论了如何利用基因表达转录后调控的多层次组成，为急性和慢性白血病的潜在治疗提供依据。
