Negash Zenebe, Yismaw Malede
Department of Pharmacology and Clinical Pharmacy, School of Pharmacy, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.
Diabetes Metab Syndr Obes. 2020 Oct 27;13:3969-3976. doi: 10.2147/DMSO.S275677. eCollection 2020.
Diabetes Mellitus is a complex, chronic disease that requires a coordinated management practice beyond blood glucose control. The disease causes chronic complications that affect the quality of the life of patients, place major pressure on the health-care system and cause a rise in diabetes-related mortality.
To determine the prevalence of chronic diabetes mellitus complications, related risk factors, and management practice among adult type 2 diabetes mellitus outpatients at Tikur Anbessa Specialized Hospital (TASH).
A cross-sectional study design was carried out from July to September 2018. The pre-tested data abstraction format was used to gather demographic and clinical information. We also used a balance of weight measurement, upright placed meter for height measurement, waist circumference measurement meter and BP equipment. Statistical analysis was accomplished using Statistical Package for the Social Sciences (SPSS) 25 software. The significance level for statistics was set at p<0.05.
In this study, 320 patients were involved. Of these, about 57% were female and had a mean age of 58 ±11.2 years. About 85% of the study participants had comorbidity and 42.5% had complications. Hypertension and neuropathy were the most common comorbidity and complication, respectively. The usage of vascular preventive medication among study participants was 74.7% and 55.3% for statins and ASAs, respectively. Participants in the study who had disease duration of 5-10 years (AOR=3.50, 95% CI: 1.19-10.28) and fifteen and above (AOR= 3.59, 95% CI: 1.36-9.49) were at higher risk of diabetes complication as compared to less than five years.
The prevalence of chronic complications was high among adult T2DM outpatients. The duration of disease and the number of medications used were the factors associated with chronic complications. The use of vascular preventive medications was low among study participants.
糖尿病是一种复杂的慢性疾病，需要超越血糖控制的协调管理措施。该疾病会引发慢性并发症，影响患者生活质量，给医疗保健系统带来巨大压力，并导致糖尿病相关死亡率上升。
确定提库尔·安贝萨专科医院（TASH）成年2型糖尿病门诊患者慢性糖尿病并发症的患病率、相关危险因素及管理措施。
于2018年7月至9月进行横断面研究设计。采用预先测试的数据提取格式收集人口统计学和临床信息。我们还使用了体重测量秤、直立式身高测量仪、腰围测量仪和血压测量设备。使用社会科学统计软件包（SPSS）25软件进行统计分析。统计学显著性水平设定为p<0.05。
本研究纳入320名患者。其中，约57%为女性，平均年龄为58±11.2岁。约85%的研究参与者患有合并症，42.5%有并发症。高血压和神经病变分别是最常见的合并症和并发症。研究参与者中他汀类药物和阿司匹林的血管预防药物使用率分别为74.7%和55.3%。与病程少于5年的参与者相比，病程为5 - 10年（调整后比值比[AOR]=3.50，95%置信区间[CI]：1.19 - 10.28）及15年及以上（AOR = 3.59，95% CI：1.36 - 9.49）的研究参与者发生糖尿病并发症的风险更高。
成年2型糖尿病门诊患者慢性并发症的患病率较高。疾病病程和所用药物数量是与慢性并发症相关的因素。研究参与者中血管预防药物的使用率较低。
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