三氯乙烯增加肺内皮通透性：对肺静脉闭塞性疾病的影响。
Trichloroethylene increases pulmonary endothelial permeability: implication for pulmonary veno-occlusive disease.
作者信息
Caliez Julien, Riou Marianne, Manaud Grégoire, Nakhleh Morad K, Quatredeniers Marceau, Rucker-Martin Catherine, Dorfmüller Peter, Lecerf Florence, Vinhas Maria C, Khatib Salam, Haick Hossam, Cohen-Kaminsky Sylvia, Humbert Marc, Montani David, Perros Frédéric
机构信息
School of Medicine, Université Paris-Saclay, Le Kremlin-Bicêtre, France.
INSERM UMR_S 999 "Pulmonary Hypertension: Pathophysiology and Novel Therapies", Hôpital Marie Lannelongue, Le Plessis-Robinson, France.
出版信息
Pulm Circ. 2020 Oct 16;10(4):2045894020907884. doi: 10.1177/2045894020907884. eCollection 2020 Oct-Dec.
Abstract
Trichloroethylene exposure is a major risk factor for pulmonary veno-occlusive disease. We demonstrated that trichloroethylene alters the endothelial barrier integrity, at least in part, through vascular endothelial (VE)-Cadherin internalisation, and suggested that this mechanism may play a role in the development of pulmonary veno-occlusive disease.
摘要
三氯乙烯暴露是肺静脉闭塞性疾病的主要危险因素。我们证明，三氯乙烯至少部分地通过血管内皮（VE）-钙黏蛋白内化改变内皮屏障的完整性，并表明这种机制可能在肺静脉闭塞性疾病的发展中起作用。
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