基于单光子雪崩二极管相机的动态时域近红外光学断层扫描技术
Dynamic time domain near-infrared optical tomography based on a SPAD camera.
作者信息
Jiang Jingjing, Costanzo Mata Aldo Di, Lindner Scott, Charbon Edoardo, Wolf Martin, Kalyanov Alexander
机构信息
Biomedical Optics Research Laboratory, University Hospital Zurich and University of Zurich, Switzerland.
Advanced Quantum Architecture Laboratory, EPFL, 2002 Neuchâtel, Switzerland.
出版信息
Biomed Opt Express. 2020 Sep 9;11(10):5470-5477. doi: 10.1364/BOE.399387. eCollection 2020 Oct 1.
Abstract
In many clinical applications it is relevant to observe dynamic changes in oxygenation. Therefore the ability of dynamic imaging with time domain (TD) near-infrared optical tomography (NIROT) will be important. But fast imaging is a challenge. The data acquisition of our handheld TD NIROT system based on single photon avalanche diode (SPAD) camera and 11 light sources was consequently accelerated. We tested the system on a diffusive medium simulating tissue with a moving object embedded. With 3D image reconstruction, the moving object was correctly located using only 0.2 s exposure time per source.
摘要
在许多临床应用中，观察氧合的动态变化具有重要意义。因此，时域（TD）近红外光学断层扫描（NIROT）的动态成像能力将至关重要。但快速成像具有挑战性。因此，我们基于单光子雪崩二极管（SPAD）相机和11个光源的手持式TD NIROT系统的数据采集得到了加速。我们在一个模拟组织的扩散介质上对该系统进行了测试，该介质中嵌入了一个移动物体。通过三维图像重建，仅使用每个光源0.2秒的曝光时间就能正确定位移动物体。
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