他汀类药物在降低卵巢癌发病率和死亡率方面起作用吗？一项系统评价与荟萃分析。
Do statins play any role in reducing the incidence and mortality of ovarian cancer? A systematic review and meta-analysis.
作者信息
Mohammadian-Hafshejani Abdollah, Sherwin Catherine M T, Heidari-Soureshjani Saeid
机构信息
Department of Epidemiology and Biostatistics, School of Public Health, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Pediatric Clinical Pharmacology, Department of Pediatrics, Wright State University Boonshoft School of Medicine, Dayton Children's Hospital, One Children's Plaza, Dayton, Ohio, USA.
出版信息
J Prev Med Hyg. 2020 Oct 6;61(3):E331-E339. doi: 10.15167/2421-4248/jpmh2020.61.3.1497. eCollection 2020 Sep.
INTRODUCTION
This systematic review and meta-analysis aimed to investigate the relationship between statin consumption and risk of incidence of ovarian cancer (OC) and associated mortality.
METHODS
Computerized searches were conducted in three electronic databases (PubMed, Web of Science, and Scopus). Two calibrated authors performed the publications selection, data extraction, and quality assessment of the selected publications. The quality of the included articles was evaluated using the Newcastle-Ottawa Scale (NOS) for observational studies, and Jadad criteria for randomized clinical trials (RCTs). The electronic searches retrieved 2272 titles/abstracts. After the deletion of duplicate publications, 2030 titles/abstracts were assessed. Eighteen articles were included.
RESULTS
Meta-analysis demonstrated that risk ratio (RR) of the association between statin consumption and OC incidence was 0.88 (95% CI = 0.75-1.03, P = 0.109). Patients receiving statin were less likely to die than those who did not receive statin, with a statistically significant association [RR = 0.76 (95% CI 0.67-0.86, P = 0.0001)]. There was no evidence of publication bias in examining the association between statin consumption and the risk of incidence and mortality from OC.
CONCLUSIONS
This study determined that statin use reduced the incidence risk of OC and significantly increased the survival in OC patients.
引言
本系统评价和荟萃分析旨在研究他汀类药物的使用与卵巢癌（OC）发病风险及相关死亡率之间的关系。
方法
在三个电子数据库（PubMed、Web of Science和Scopus）中进行计算机检索。两名经过校准的作者对选定的出版物进行了筛选、数据提取和质量评估。使用纽卡斯尔-渥太华量表（NOS）对观察性研究进行纳入文章的质量评估，使用 Jadad 标准对随机临床试验（RCT）进行评估。电子检索共获得2272个标题/摘要。删除重复出版物后，对2030个标题/摘要进行了评估。纳入了18篇文章。
结果
荟萃分析表明，他汀类药物使用与OC发病率之间关联的风险比（RR）为0.88（95%可信区间[CI]=0.75-1.03，P=0.109）。接受他汀类药物治疗的患者死亡可能性低于未接受他汀类药物治疗的患者，具有统计学意义的关联[RR=0.76（95%CI 0.67-0.86，P=0.0001）]。在研究他汀类药物使用与OC发病风险和死亡率之间的关联时，没有证据表明存在发表偏倚。
结论
本研究确定他汀类药物的使用降低了OC的发病风险，并显著提高了OC患者的生存率。
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