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老年人接种流感疫苗与急性脑血管意外及其住院的关系的系统评价和荟萃分析。

A Systematic Review and Meta-Analysis of the Relationship between Receiving the Flu Vaccine with Acute Cerebrovascular Accident and Its Hospitalization in the Elderly.

机构信息

Department of Epidemiology and Biostatistics, School of Health, Shahrekord University of Medical Sciences, Shahrekord, Iran.

Department of Epidemiology, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.

出版信息

Biomed Res Int. 2023 Feb 13;2023:2606854. doi: 10.1155/2023/2606854. eCollection 2023.

DOI:10.1155/2023/2606854
PMID:36814798
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9940958/
Abstract

BACKGROUND AND AIMS

In recent years, various studies have been conducted worldwide to investigate the relationship between receiving the flu vaccine with acute cerebrovascular accident or stroke and its hospitalization in the elderly; however, the results of these studies are contradictory. Therefore, this study was aimed at investigating the relationship between receiving the flu vaccine with stroke and its hospitalization in the elderly.

METHODS

This study is a systematic review and meta-analysis of studies examining the relationship between receiving the flu vaccine with stroke and its hospitalization in the elderly during the years 1980 to 2021 which have been published in ISI Web of Science, Scopus PubMed, Cochrane, Science Direct, Google Scholar, and Embase. All analyses were performed by Stata 15, and the significance level in this study was considered <0.05.

RESULTS

In the systematic search, 3088 articles were retrieved, considering the study criteria; finally, 14 studies were included in the meta-analysis. Based on the results of the meta-analysis, the odds ratio (OR) of occurrence and hospitalization of stroke compared to the nonvaccinated group in vaccine recipients is equal to 0.84 (95% confidence interval (CI): 0.78-0.90, value ≤ 0.001). Publication bias was not observed in this study ( value = 0.101).

CONCLUSION

Getting the flu vaccine can reduce the risk of occurrence and hospitalization of stroke in the elderly by 16% (10%-22%). Therefore, receiving this vaccine as a preventive intervention for stroke in the elderly may be promising.

摘要

背景与目的

近年来，全球范围内开展了多项研究，旨在探讨老年人接种流感疫苗与急性脑血管意外或中风及其住院治疗之间的关系，但研究结果相互矛盾。因此，本研究旨在调查老年人接种流感疫苗与中风及其住院治疗之间的关系。

方法

本研究对 1980 年至 2021 年期间在 ISI Web of Science、Scopus、PubMed、Cochrane、Science Direct、Google Scholar 和 Embase 上发表的评估流感疫苗接种与老年人中风及其住院治疗之间关系的研究进行了系统性回顾和荟萃分析。所有分析均采用 Stata 15 进行，本研究的显著性水平设为<0.05。

结果

在系统检索中，共检索到 3088 篇文章，考虑到研究标准，最终纳入了 14 项荟萃分析研究。基于荟萃分析结果，与未接种疫苗组相比，疫苗接种组中风发生和住院的比值比（OR）为 0.84（95%置信区间（CI）：0.78-0.90， 值≤0.001）。本研究未观察到发表偏倚（ 值=0.101）。

结论

接种流感疫苗可使老年人中风发生和住院风险降低 16%（10%-22%）。因此，将该疫苗作为老年人中风的预防干预措施可能具有一定前景。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a19e/9940958/4892a0fb57fc/BMRI2023-2606854.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a19e/9940958/7041ffd69159/BMRI2023-2606854.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a19e/9940958/ad60809d6c96/BMRI2023-2606854.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a19e/9940958/cee77fbb7e11/BMRI2023-2606854.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a19e/9940958/3e01a1d75617/BMRI2023-2606854.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a19e/9940958/4892a0fb57fc/BMRI2023-2606854.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a19e/9940958/7041ffd69159/BMRI2023-2606854.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a19e/9940958/ad60809d6c96/BMRI2023-2606854.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a19e/9940958/cee77fbb7e11/BMRI2023-2606854.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a19e/9940958/3e01a1d75617/BMRI2023-2606854.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a19e/9940958/4892a0fb57fc/BMRI2023-2606854.005.jpg

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