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Hydrus微支架在黑人及非裔拉丁裔青光眼患者中的真实世界疗效:一项回顾性研究。

Real-world efficacy of the Hydrus microstent in Black and Afro-Latinx patients with glaucoma: a retrospective study.

作者信息

Laroche Daniel, Nkrumah Gideon, Ng Chester

机构信息

Advanced Eyecare of New York, 49 West 127th Street, New York, NY 10027, USA.

School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.

出版信息

Ther Adv Ophthalmol. 2020 Oct 19;12:2515841420964311. doi: 10.1177/2515841420964311. eCollection 2020 Jan-Dec.

Abstract

PURPOSE

The purpose was to determine the real-world efficacy of phacoemulsification cataract surgery and Hydrus microstent in Black and Afro-Latinx patients with glaucoma.

METHODS

A retrospective noncomparative single-center study of 76 Black and Afro-Latinx patients with glaucoma who underwent phacoemulsification cataract surgery and Hydrus microstent placement for treatment of glaucoma at single practice. Investigated parameters were intraocular pressure (IOP), number of medications, mean deviation on visual field test, and visual acuity. Patients were also subgrouped into mild, moderate, and advance glaucoma for further analysis.

RESULTS

We reviewed a total of 76 patients who had 6 months of follow up in the study. The mean number of medications decreased significantly from 2.6 ± 1.5 preoperatively to 0.72 ± 1.4 in 6 months ( < 0.0010), while IOP decreased from 14.7 ± 3.7 to 13.9 ± 4.3 ( = 0.25). At 6 months, 55 patients (74%) of all patients were medication free ( = 27, 84.4% mild glaucoma;  = 17, 70.8% moderate glaucoma;  = 10, 50% advance glaucoma). There was significant improvement in visual acuity ( < 0.00010) and stabilization of mean deviation on visual field test (baseline -9.2; 6 months -9.1;  = 0.22). The most common adverse effect was a transient IOP spike and transient corneal edema ( = 6, 7.9%;  = 6, 7.9%, respectively) with spontaneous resolution in all cases. No sight-threatening complications were reported at 6 months.

CONCLUSION/CLINICAL RELEVANCE: This 6-month retrospective study demonstrated the efficacy of phacoemulsification cataract surgery and Hydrus microstent in reducing the medication burden while maintaining lower IOP in Black and Afro-Latinx patients with glaucoma.

摘要

目的

本研究旨在确定白内障超声乳化手术联合Hydrus微支架植入术对患有青光眼的黑人和非裔拉丁裔患者的实际疗效。

方法

这是一项回顾性、非对照、单中心研究,纳入了76例患有青光眼的黑人和非裔拉丁裔患者,这些患者在单一医疗机构接受了白内障超声乳化手术及Hydrus微支架植入术以治疗青光眼。研究参数包括眼压(IOP)、药物使用数量、视野测试中的平均偏差以及视力。患者还被分为轻度、中度和重度青光眼亚组以进行进一步分析。

结果

我们共回顾了76例患者,这些患者在研究中均接受了6个月的随访。药物使用的平均数量从术前的2.6±1.5显著降至6个月时的0.72±1.4(<0.0010),而眼压从14.7±3.7降至13.9±4.3(=0.25)。6个月时,所有患者中有55例(74%)无需使用药物(轻度青光眼患者27例,占84.4%;中度青光眼患者17例,占70.8%;重度青光眼患者10例,占50%)。视力有显著改善(<0.00010),视野测试中的平均偏差保持稳定(基线为-9.2;6个月时为-9.1;=0.22)。最常见的不良反应是短暂的眼压升高和短暂的角膜水肿(分别为6例,占7.9%;6例,占7.9%),所有病例均自行缓解。6个月时未报告有威胁视力的并发症。

结论/临床意义:这项为期6个月的回顾性研究表明,白内障超声乳化手术联合Hydrus微支架植入术在减轻患有青光眼的黑人和非裔拉丁裔患者的药物负担同时维持较低眼压方面具有疗效。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7176/7580146/c1735e0f2120/10.1177_2515841420964311-fig1.jpg

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