Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, 1060 William Moore Dr., Raleigh, NC, 27607, USA.
Center for Comparative Medicine and Translational Research, North Carolina State University, 1060 William Moore Dr, Raleigh, NC, 27607, USA.
Inflammation. 2021 Apr;44(2):450-465. doi: 10.1007/s10753-020-01362-2. Epub 2020 Nov 5.
Asthma is a common and debilitating chronic airway disease that affects people and horses of all ages worldwide. While asthma in humans most commonly involves an excessive type 2 immune response and eosinophilic inflammation, neutrophils have also been recognized as key players in the pathophysiology of asthma, including in the severe asthma phenotype where neutrophilic inflammation predominates. Severe equine asthma syndrome (sEAS) features prominent neutrophilic inflammation and has been increasingly used as a naturally occurring animal model for the study of human neutrophilic asthma. This comparative review examines the recent literature in order to explore the role of neutrophil inflammatory functions in the pathophysiology and immunology of asthma in humans and horses.
哮喘是一种常见且使人虚弱的慢性气道疾病，影响着全世界各个年龄段的人和马。虽然人类哮喘最常见的是涉及过度的 2 型免疫反应和嗜酸性粒细胞炎症，但中性粒细胞也已被认为是哮喘病理生理学的关键参与者，包括在以中性粒细胞炎症为主的严重哮喘表型中。严重马哮喘综合征（sEAS）的特征是明显的中性粒细胞炎症，并且已越来越多地被用作研究人类中性粒细胞性哮喘的天然发生动物模型。本综述性比较研究检查了最近的文献，以探讨中性粒细胞炎症功能在人类和马的哮喘病理生理学和免疫学中的作用。
Zotero 插件