Instituto de Farmacología y Morfofisiología, Facultad de Ciencias Veterinarias, Universidad Austral de Chile, Valdivia, Chile.
Instituto de Ciencias Clínicas Veterinarias, Facultad de Ciencias Veterinarias, Universidad Austral de Chile, Valdivia, Chile.
Front Immunol. 2022 Apr 12;13:850416. doi: 10.3389/fimmu.2022.850416. eCollection 2022.
Neutrophil extracellular traps (NETs) are a recently described mechanism of neutrophils that play an important role in health and disease. NETs are an innate defense mechanism that participate in clearance of pathogens, but they may also cause collateral damage in unrelated host tissues. Neutrophil dysregulation and NETosis occur in multiple lung diseases, such as pathogen-induced acute lung injury, pneumonia, chronic obstructive pulmonary disease (COPD), severe asthma, cystic fibrosis, and recently, the novel coronavirus SARS-CoV-2. More recently, research into immunometabolism has surged due to the possibility of reprogramming metabolism in order to modulate immune functions. The present review analyzes the different metabolic pathways associated with NETs formation, and how these impact on pathologies of the airways.
中性粒细胞胞外陷阱（NETs）是一种新近描述的中性粒细胞机制，在健康和疾病中发挥着重要作用。NETs 是一种先天防御机制，参与清除病原体，但它们也可能在无关的宿主组织中造成附带损伤。中性粒细胞失调和 NETosis 发生在多种肺部疾病中，如病原体引起的急性肺损伤、肺炎、慢性阻塞性肺疾病（COPD）、严重哮喘、囊性纤维化，最近还有新型冠状病毒 SARS-CoV-2。最近，由于有可能重新编程代谢以调节免疫功能，免疫代谢的研究出现了激增。本综述分析了与 NETs 形成相关的不同代谢途径，以及这些途径如何影响气道的病理学。
