长链非编码 RNA SNHG6 通过增强 YBX1 介导的 HIF1α 翻译促进肾透明细胞癌的发生。
Long noncoding RNA SNHG6 promotes carcinogenesis by enhancing YBX1-mediated translation of HIF1α in clear cell renal cell carcinoma.
机构信息
Department of Pathology, Rui Jin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Department of Pathology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
出版信息
FASEB J. 2021 Feb;35(2):e21160. doi: 10.1096/fj.202000732RR. Epub 2020 Nov 4.
Recent studies have showed that Small nucleolar RNA host genes (SNHGs) acted as a subset of long noncoding RNAs (lncRNAs) have critical roles in human cancer carcinogenesis. However, the biological functions of SNHGs in clear cell renal cell carcinoma (ccRCC) have not been fully investigated. In this study, we screened an oncogenic lncRNA termed SNHG6 using RNA-Seq data of ccRCC from The Cancer Genome Atlas (TCGA). Quantitative real-time PCR was then used to demonstrate the expression of SNHG6 in ccRCC tissues. SNHG6 overexpression is highly associated with malignant features in patients and is a prognostic indicator. SNHG6 significantly promotes ccRCC cell proliferation and metastasis in vitro and in vivo. Mechanistic investigations identified that SNHG6 exerts oncogenic effects by interacting with YBX1, and then, enhancing HIF1α translation. Taken together, SNHG6 promotes ccRCC progression by binding YBX1 and may serve as a novel molecular target for ccRCC therapy.
最近的研究表明，小核仁 RNA 宿主基因（SNHGs）作为长非编码 RNA（lncRNAs）的一个子集，在人类癌症发生中具有关键作用。然而，SNHGs 在透明细胞肾细胞癌（ccRCC）中的生物学功能尚未被充分研究。在这项研究中，我们使用来自癌症基因组图谱（TCGA）的 ccRCC 的 RNA-Seq 数据筛选出一种致癌的 lncRNA，称为 SNHG6。然后使用定量实时 PCR 来证明 SNHG6 在 ccRCC 组织中的表达。SNHG6 的过表达与患者的恶性特征高度相关，是一个预后指标。SNHG6 显著促进 ccRCC 细胞在体外和体内的增殖和转移。机制研究表明，SNHG6 通过与 YBX1 相互作用，从而增强 HIF1α 的翻译，发挥致癌作用。总之，SNHG6 通过与 YBX1 结合促进 ccRCC 的进展，可能成为 ccRCC 治疗的新分子靶点。
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