• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

患有 2 型糖尿病的正常白蛋白尿成年人在超过 14 年的时间里存在肾小管损伤的高风险。

High risk of tubular damage in normoalbuminuric adults with type 2 diabetes for over 14 years.

机构信息

Central Laboratory, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, China.

Department of Clinical Laboratory, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, China.

出版信息

J Diabetes. 2021 Mar;13(3):261-264. doi: 10.1111/1753-0407.13131. Epub 2020 Nov 22.

DOI:10.1111/1753-0407.13131
PMID:33150688
Abstract

Highlights The level of urinary α -microglobulin to creatinine ratio (A1MCR) increases with longer diabetes duration. Patients with a diabetes duration >14 years have a higher tubular damage rate. Being male and a diabetes duration >14 years have an interaction effect on increased A1MCR.

摘要

要点

尿α-微球蛋白与肌酐比值（A1MCR）随糖尿病病程延长而升高。糖尿病病程>14 年的患者肾小管损伤率较高。男性和糖尿病病程>14 年对 A1MCR 的升高有交互作用。

相似文献

1
High risk of tubular damage in normoalbuminuric adults with type 2 diabetes for over 14 years.患有 2 型糖尿病的正常白蛋白尿成年人在超过 14 年的时间里存在肾小管损伤的高风险。
J Diabetes. 2021 Mar;13(3):261-264. doi: 10.1111/1753-0407.13131. Epub 2020 Nov 22.
2
High ACR level is a strong risk factor for renal tubular impairment in patients with type 2 diabetes: A longitudinal observational study.高 ACR 水平是 2 型糖尿病患者肾小管损伤的一个强烈危险因素：一项纵向观察性研究。
Diabetes Res Clin Pract. 2020 Jul;165:108272. doi: 10.1016/j.diabres.2020.108272. Epub 2020 Jun 16.
3
Urinary kidney injury molecule-1 and neutrophil gelatinase-associated lipocalin as indicators of tubular damage in normoalbuminuric patients with type 2 diabetes.尿肾损伤分子-1和中性粒细胞明胶酶相关脂质运载蛋白作为2型糖尿病正常白蛋白尿患者肾小管损伤的指标
Clin Biochem. 2016 Feb;49(3):232-6. doi: 10.1016/j.clinbiochem.2015.10.016. Epub 2015 Oct 27.
4
Significant association of urinary alpha-1-microglobulin compared to urinary neutrophil gelatinase-associated lipocalin with renal insufficiency in patients with type 2 diabetes.与尿中性粒细胞明胶酶相关脂质运载蛋白相比，尿α-1-微球蛋白与 2 型糖尿病患者肾功能不全有显著相关性。
Nephrology (Carlton). 2021 May;26(5):400-407. doi: 10.1111/nep.13851. Epub 2021 Feb 2.
5
Estimating the glomerular filtration rate and tubular dysfunction in an elderly population with normoalbuminuria in China.估算中国正常白蛋白尿老年人群的肾小球滤过率和肾小管功能障碍。
Clin Chim Acta. 2019 Aug;495:377-381. doi: 10.1016/j.cca.2019.05.009. Epub 2019 May 9.
6
Proximal tubule dysfunction is dissociated from endothelial dysfunction in normoalbuminuric patients with type 2 diabetes mellitus: a cross-sectional study.正常白蛋白尿 2 型糖尿病患者近端小管功能障碍与内皮功能障碍分离：一项横断面研究。
Nephron Clin Pract. 2011;118(2):c155-64. doi: 10.1159/000320038. Epub 2010 Dec 10.
7
High normal albuminuria is independently associated with aortic stiffness in patients with Type 2 diabetes.在2型糖尿病患者中，高正常白蛋白尿与主动脉僵硬度独立相关。
Diabet Med. 2014 Oct;31(10):1199-204. doi: 10.1111/dme.12461. Epub 2014 Apr 23.
8
Urinary orosomucoid 1 protein to creatinine ratio as a potential biomarker for early screening of kidney impairment in type-2 diabetes patients.尿唾液酸糖蛋白 1 与肌酐比值作为 2 型糖尿病患者早期肾脏损伤筛查的潜在生物标志物。
Nephrology (Carlton). 2020 Sep;25(9):667-675. doi: 10.1111/nep.13707. Epub 2020 Mar 24.
9
Podocyturia parallels proximal tubule dysfunction in type 2 diabetes mellitus patients independently of albuminuria and renal function decline: A cross-sectional study.微量白蛋白尿与 2 型糖尿病患者近端肾小管功能障碍平行，与蛋白尿和肾功能下降无关：一项横断面研究。
J Diabetes Complications. 2017 Sep;31(9):1444-1450. doi: 10.1016/j.jdiacomp.2017.01.007. Epub 2017 Jan 20.
10
Associations of urinary, glomerular, and tubular markers with the development of diabetic kidney disease in type 2 diabetes patients.2型糖尿病患者中尿、肾小球及肾小管标志物与糖尿病肾病发生的相关性。
J Clin Lab Anal. 2018 Jan;32(1). doi: 10.1002/jcla.22191. Epub 2017 Feb 25.

引用本文的文献

1
Receiver Operator Characteristic (ROC) Analysis of Lipids, Proteins, DNA Oxidative Damage, and Antioxidant Defense in Plasma and Erythrocytes of Young Reproductive-Age Men with Early Stages of Type 1 Diabetes Mellitus (T1DM) Nephropathy in the Irkutsk Region, Russia.俄罗斯伊尔库茨克地区1型糖尿病（T1DM）肾病早期年轻育龄男性血浆和红细胞中脂质、蛋白质、DNA氧化损伤及抗氧化防御的受试者工作特征（ROC）分析
Metabolites. 2022 Dec 16;12(12):1282. doi: 10.3390/metabo12121282.