Electron Science Research Institute, Edith Cowan University, Joondalup, Western Australia, Australia.
Lazcath PTY LTD, Mosman Park, Western Australia, Australia.
J Biophotonics. 2021 Feb;14(2):e202000243. doi: 10.1002/jbio.202000243. Epub 2020 Nov 25.
The inability of current catheter ablation procedures to accurately monitor lesion formation limits their safety and efficacy. An advanced fully integrated radiofrequency (RF)/optical coherence tomography (OCT) ablation catheter is developed, which enables real-time monitoring during ablation. An OCT fiber array is especially designed, developed and integrated into an off-the-shelf irrigated RF ablation catheter. In-vitro experimental studies performed on poultry and ovine hearts demonstrate the ability of the integrated RF/OCT system to provide information on the quality and orientation of catheter/wall contact. Experimental results show that adipose tissue can be accurately identified from normal myocardial tissue with 94% accuracy and lesion formation is monitored with an overall accuracy of 93%. The ability to predict pop events is also demonstrated, with an accuracy of 86%.
目前的导管消融术无法准确监测病变形成，限制了其安全性和有效性。本文开发了一种先进的全集成射频（RF）/光学相干断层扫描（OCT）消融导管，可实现消融过程中的实时监测。专门设计、开发和集成了 OCT 光纤阵列到市售的灌流 RF 消融导管中。在禽类和羊的心脏上进行的体外实验研究表明，集成的 RF/OCT 系统能够提供导管/壁接触的质量和方向信息。实验结果表明，该系统能够以 94%的准确率从正常心肌组织中准确识别脂肪组织，并以 93%的总体准确率监测病变形成。还证明了该系统能够以 86%的准确率预测消融穿孔事件。
