Department of Clinical Laboratory, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Children's Regional Medical Center, Hangzhou, China.
J Med Virol. 2021 Mar;93(3):1387-1395. doi: 10.1002/jmv.26653. Epub 2020 Nov 22.
The lungs are the most commonly affected organ by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), but the kidneys are also frequently affected. Infection with SARS-CoV-2 can not only cause new kidney damage but also increase the difficulty of treatment and care as well as mortality for people with underlying kidney diseases. Kidney involvement in SARS-CoV-2 infection mainly manifests as kidney tubular injury. Proteinuria is the main clinical sign. To reduce patient mortality, kidney complications should be given increased attention in the diagnosis and treatment of coronavirus disease 2019 (COVID-19). This study reviews the existing literature and discusses COVID-19 infection in combination with kidney diseases in terms of kidney damage, pathogenesis, and treatment to guide clinical anti-epidemic responses.
肺部是严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）感染最常累及的器官，但肾脏也常受影响。SARS-CoV-2 感染不仅会导致新的肾脏损伤，还会增加基础肾脏疾病患者的治疗和护理难度以及死亡率。SARS-CoV-2 感染导致的肾脏受累主要表现为肾小管损伤，蛋白尿是主要的临床征象。为降低患者死亡率，在诊治 2019 冠状病毒病（COVID-19）时应更加关注肾脏并发症。本文复习了现有文献，就 COVID-19 感染合并肾脏疾病的肾脏损伤、发病机制和治疗等方面进行讨论，旨在为临床抗疫提供指导。
