Lin Lirong, Deng Junhui, Tan Wei, Li Jie, Wu Zhifeng, Zheng Luquan, Yang Jurong
Department of Nephrology, The Third Affiliated Hospital of Chongqing Medical University (Gener Hospital), Chongqing, China.
Department of Nephrology, Yongchuan People's Hospital of Chongqing, Chongqing, China.
J Med Virol. 2023 Jan;95(1):e28311. doi: 10.1002/jmv.28311.
Coronavirus disease 2019 (COVID-19) can cause damage to multiple organ, not only to the lungs, but also to the kidneys. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can cause acute and chronic kidney disease through direct viral infection, indirect injury, and vaccination-related injury. Like lung injury, kidney injury is also an important aspect affecting the severity and prognosis of SARS-CoV-2. This article summarizes the pathogenesis, pathological manifestations, and clinical features of SARS-CoV-2 direct or indirect renal injury. Including direct injury, indirect injury, special comorbidities (receiving kidney transplantation and chronic kidney disease), and vaccine-related renal injury, and exploring the possible therapeutic effect of anti-SARS-CoV-2 therapy on renal injury. The purpose is to provide reference for understanding COVID-19-related renal injury, guiding clinical and pathological diagnosis and treatment, and evaluating prognosis.
2019冠状病毒病（COVID-19）可导致多器官损害，不仅累及肺部，还会影响肾脏。严重急性呼吸综合征冠状病毒2（SARS-CoV-2）可通过直接病毒感染、间接损伤和疫苗相关损伤引发急性和慢性肾脏疾病。与肺损伤一样，肾损伤也是影响SARS-CoV-2严重程度和预后的重要方面。本文总结了SARS-CoV-2直接或间接肾损伤的发病机制、病理表现及临床特征，包括直接损伤、间接损伤、特殊合并症（接受肾移植和慢性肾脏病）以及疫苗相关肾损伤，并探讨抗SARS-CoV-2治疗对肾损伤可能的治疗作用，旨在为理解COVID-19相关肾损伤、指导临床及病理诊断治疗和评估预后提供参考。
