一锅四组分偶联方法构建多杂环：6-呋喃并[3,2-]吡咯并[1,2-][1,4]二氮杂卓。
One-Pot Four-Component Coupling Approach to Polyheterocycles: 6-Furo[3,2-]pyrrolo[1,2-][1,4]diazepine.
机构信息
Graduate Program of Industrial Pharmaceutical Sciences, Yonsei University, 85 Songdogwahak-ro, Yeonsu-gu, Incheon 21983, Republic of Korea.
College of Pharmacy and Yonsei Institute of Pharmaceutical Sciences, Yonsei University, 85 Songdogwahak-ro, Yeonsu-gu, Incheon 21983, Republic of Korea.
出版信息
J Org Chem. 2020 Dec 4;85(23):15082-15091. doi: 10.1021/acs.joc.0c01971. Epub 2020 Nov 5.
A novel polyheterocyclic chemical space, 6-furo[3,2-]pyrrolo[1,2-][1,4]diazepine, was generated by a one-pot four-component coupling reaction where multiple bonds (three C-C, one C-O, and one C-N) were formed through a domino sequence. Two heterocyclic rings (furan and diazepine) were sequentially constructed from the monocyclic pyrrole derivative under environment-friendly reaction conditions to furnish the tricyclic fused scaffold.
一种新型聚杂环化学空间 6-呋喃并[3,2-]吡咯并[1,2-][1,4]二氮杂卓，是通过一锅四组分偶联反应生成的，其中多个键（三个 C-C、一个 C-O 和一个 C-N）通过多米诺序列形成。两个杂环（呋喃和二氮杂卓）从单环吡咯衍生物中在环保的反应条件下依次构建，从而得到三环稠合支架。
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