小分子一锅法逐步合成（OPSS）的最新进展。
Recent developments in one-pot stepwise synthesis (OPSS) of small molecules.
作者信息
Ma Xiaoming, Zhang Wei
机构信息
School of Pharmacy, Changzhou University, Jiangsu 213164, China.
Department of Chemistry, University of Massachusetts Boston, MA 02125, USA.
出版信息
iScience. 2022 Aug 27;25(9):105005. doi: 10.1016/j.isci.2022.105005. eCollection 2022 Sep 16.
One-pot synthesis is an active topic in organic chemistry due to its intrinsic advantages of simple operation, high mass efficiency, low cost, and less amount of waste disposal. Among three kinds of one-pot syntheses, 1) cascade reactions, 2) multicomponent reactions (MCRs), and 3) one-pot stepwise synthesis (OPSS), OPSS could be more flexible and practical since it is carried out stepwisely and have variable reaction conditions for different steps. This perspective article uses selected examples to highlight the recent development in OPSS involving cyclization, cycloaddition, rearrangement, and catalytic reactions for the synthesis of heterocyclic scaffolds, asymmetric molecules, natural products, and bioactive compounds.
一锅法合成因其操作简单、质量效率高、成本低以及废物处理量少等固有优点，是有机化学中的一个活跃课题。在三种一锅法合成中，1）串联反应，2）多组分反应（MCRs），以及3）一锅逐步合成（OPSS），OPSS可能更灵活、更实用，因为它是逐步进行的，并且不同步骤具有可变的反应条件。这篇综述文章通过选定的实例，突出了OPSS在涉及环化、环加成、重排以及用于合成杂环骨架、不对称分子、天然产物和生物活性化合物的催化反应方面的最新进展。
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