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骨代谢是胫骨平台骨折临床转归的关键因素。

Bone metabolism is a key factor for clinical outcome of tibial plateau fractures.

机构信息

Department of Trauma and Orthopaedic Surgery, University Medical Center Hamburg-Eppendorf, Martini Str. 52, 20246, Hamburg, Germany.

BG Trauma Hospital Hamburg, Hamburg, Germany.

出版信息

Eur J Trauma Emerg Surg. 2020 Dec;46(6):1227-1237. doi: 10.1007/s00068-020-01537-4. Epub 2020 Nov 5.

Abstract

PURPOSE

Given that tibial plateau fractures (TPF) are rare, they may pose a challenge to the treating surgeon due to their variety of complex fracture patterns. Numerous studies have identified potential fracture-specific, surgery-related, and patient-related risk factors for impaired patient outcomes. However, reports on the influence of bone metabolism on functional outcomes are missing.

METHODS

In a retrospective multicenter cohort study, 122 TPF of 121 patients were analyzed with respect to radiological and clinical outcomes (Rasmussen) with a mean follow-up of 35.7 ± 24.9 months. The risk factor assessment included bone metabolism-affecting comorbidities and medication.

RESULTS

The findings showed that 95.9% of the patients reported a good-to-excellent clinical outcome, and 97.4% reported a good-to-excellent radiological outcome. Logistic regression revealed that potentially impaired bone metabolism (IBM) was an independent risk factor for the clinical (p = 0.016) but not the radiological outcome (Table 4). Patients with 41-type B fractures and a potential IBM had a seven times higher risk to present a fair-to-poor clinical outcome [OR 7.45, 95 CI (4.30, 12.92)]. The most common objective impairment was a limited range of motion in 16.4% of the patients, especially in 41-type C fractures (p = 0.06). The individual failure analysis additionally identified surgery-related options for improvement.

CONCLUSION

This study demonstrated that potential IBM was an independent risk factor for a poor-to-fair clinical outcome.

摘要

目的

由于胫骨平台骨折(TPF)较为罕见,其具有多种复杂的骨折模式,可能对治疗医生构成挑战。大量研究已经确定了潜在的与骨折特异性、手术相关和患者相关的影响患者预后的风险因素。然而,关于骨代谢对功能结果的影响的报告尚缺乏。

方法

在一项回顾性多中心队列研究中,对 121 例患者的 122 例胫骨平台骨折进行了影像学和临床结果(Rasmussen)分析,平均随访 35.7±24.9 个月。风险因素评估包括影响骨代谢的合并症和药物。

结果

研究结果显示,95.9%的患者报告临床结果良好至优秀,97.4%报告影像学结果良好至优秀。Logistic 回归显示,潜在的骨代谢受损(IBM)是临床结果(p=0.016)但不是影像学结果(表 4)的独立风险因素。41 型 B 型骨折和潜在 IBM 的患者出现临床结果一般至差的风险增加七倍[OR 7.45,95%CI(4.30,12.92)]。最常见的客观损害是 16.4%的患者活动范围受限,尤其是 41 型 C 型骨折(p=0.06)。个体失败分析还确定了可改善的手术相关选项。

结论

本研究表明,潜在的 IBM 是临床结果差至一般的独立风险因素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d617/7691299/588e4de214b1/68_2020_1537_Fig1_HTML.jpg

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