School of Natural Sciences, Technology and Environmental Studies, Södertörn University, Alfred Nobels allé 7, 141 89, Huddinge, Sweden.
Arch Environ Contam Toxicol. 2020 Nov;79(4):478-487. doi: 10.1007/s00244-020-00776-1. Epub 2020 Nov 5.
Selective serotonin reuptake inhibitors (SSRIs) are psychotropic pharmaceuticals used as antidepressants. SSRIs are commonly found in surface waters in populated areas across the globe. They exert their effect by blocking the serotonin re-uptake transporter in the presynaptic nerve ending. The present study examined whether behavioural effects to exposure to SSRI citalopram depend on personality and sex in the stickleback (Gasterosteus aculeatus). Three aspects of stickleback behaviour are examined: feeding behaviour, aggression, and boldness. We exposed sticklebacks to 350-380 ng/l citalopram for 3 weeks. Feeding and aggressive behaviour were recorded before and after exposure, whereas scototaxis behaviour was tested after exposure. The results show treatment effects in feeding and aggressive behaviour. Feeding is suppressed only in the male group (χ = 20.4, P < 0.001) but not in the females (χ = 0.91, P = 0.339). Aggressive behaviour was significantly affected by treatment (χ = 161.9, P < 0.001), sex (χ = 86.3, P < 0.001), and baseline value (χ = 58.8, P < 0.001). Aggressiveness was suppressed by citalopram treatment. In addition, the fish showed no change in aggression and feeding behaviour over time regardless of sex and treatment, which indicate personality traits. Only females are affected by treatment in the scototaxis test. The exposed females spent significantly (χ = 5.02, P = 0.050) less time in the white zone than the female controls.
选择性 5-羟色胺再摄取抑制剂（SSRIs）是一种精神药物，用作抗抑郁药。SSRIs 在全球人口密集地区的地表水 中普遍存在。它们通过阻断突触前神经末梢中的 5-羟色胺再摄取转运蛋白来发挥作用。本研究检 查了暴露于 SSRI 西酞普兰是否会因个性和性别的不同而对棘鱼（Gasterosteus aculeatus）产生行为 影响。研究检查了棘鱼的三个行为方面：摄食行为、攻击性和大胆。我们将棘鱼暴露于 350-380ng/L 的西酞普兰中 3 周。在暴露前后记录摄食和攻击行为，而在暴露后测试 scototaxis 行为。结果显示 治疗对摄食和攻击行为有影响。摄食仅在雄性组中受到抑制（χ=20.4，P<0.001），而在雌性组中没有（χ=0.91，P=0.339）。攻击行为受到治疗（χ=161.9，P<0.001）、性别（χ=86.3，P<0.001）和基线值（χ=58.8，P<0.001）的影响。西酞普兰治疗抑制了攻击性。此外，无论性别和治疗如何，鱼的攻击和摄食行为都没有随时间变化，这表明了个性特征。只有雌性在 scototaxis 测试中受到治疗的影响。暴露的雌性在白色区域花费的时间明显（χ=5.02，P=0.050）少于雌性对照组。
