产前暴露于全氟烷基物质与脐带血浆脂质浓度。
Prenatal exposure to perfluoroalkyl substances and cord plasma lipid concentrations.
机构信息
National Management Office of Neonatal Screening Project for CHD, Children's Hospital of Fudan University, 399 Wanyuan Road, Shanghai, 201102, China; NHC Key Laboratory of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Fudan University, 779 Old Hu Min Road, Shanghai, 200237, China.
NHC Key Laboratory of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Fudan University, 779 Old Hu Min Road, Shanghai, 200237, China.
出版信息
Environ Pollut. 2021 Jan 1;268(Pt A):115426. doi: 10.1016/j.envpol.2020.115426. Epub 2020 Aug 21.
The effect of prenatal exposure to perfluoroalkyl substances (PFAS) on lipid concentrations in newborns is unknown. Using data from the Shanghai-Minhang Birth Cohort Study, we prospectively assessed the health effects of prenatal exposure to individual and multiple PFAS on cord lipid concentrations. Maternal plasma samples collected at 12-16 weeks of gestation were analyzed for eleven PFAS, and cord blood samples were analyzed for lipids: total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C). We used multiple linear regression models to evaluate the associations of each individual PFAS with each lipid parameter, and used Bayesian Kernel Machine Regression (BKMR) models to assess the overall and single-exposure effects of eight PFAS with the detection rate above 80% on cord lipid concentrations. In multiple linear regression models, for each unit increase in ln-transformed maternal concentrations of perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA), perfluoroundecanoic acid (PFUdA), and perfluorotridecanoic acid (PFTrDA), ln-transformed TC concentration decreased by 0.15 mg/dL (95% confidence interval (CI): -0.25, -0.05), 0.12 mg/dL (95% CI: -0.19, -0.05), 0.12 mg/dL (95% CI: -0.19, -0.05), and 0.05 mg/dL (95% CI: -0.09, -0.01), respectively, and ln-transformed HDL-C concentration decreased by 0.17 mg/dL (95% CI: -0.29, -0.05), 0.12 mg/dL (95% CI: -0.20, -0.03), 0.12 mg/dL (95% CI: -0.20, -0.03), and 0.06 mg/dL (95% CI: -0.11, -0.00), respectively. Statistically significant inverse associations were also observed between ln-transformed concentrations of PFDA, PFUdA, or PFTrDA and ln-transformed cord concentrations of TG and LDL-C. In BKMR models, the mixture of eight PFAS showed suggestively inverse association with all ln-transformed lipid concentrations, such that ln-transformed TC concentration of exposure to the 75th percentile of the mixture was 0.11 units (95% credible interval, -0.21, -0.01) lower than the 25th percentile exposure. Our findings indicated that prenatal exposure to PFAS may disrupt lipid metabolism in newborns.
产前暴露于全氟烷基物质（PFAS）对新生儿脂质浓度的影响尚不清楚。本研究使用来自上海-闵行出生队列研究的数据，前瞻性评估了产前暴露于个体和多种 PFAS 对脐带脂质浓度的健康影响。在妊娠 12-16 周时采集母亲的血浆样本，分析了 11 种 PFAS，采集脐带血样本分析了总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）和低密度脂蛋白胆固醇（LDL-C）。我们使用多元线性回归模型评估了每种 PFAS 与每种脂质参数的关联，使用贝叶斯核机器回归（BKMR）模型评估了 8 种 PFAS 的整体和单一暴露效应，这些 PFAS 的检出率高于 80%，对脐带脂质浓度的影响。在多元线性回归模型中，对于母体 ln 转化浓度每增加一个单位的全氟壬酸（PFNA）、全氟癸酸（PFDA）、全氟十一烷酸（PFUdA）和全氟十三烷酸（PFTrDA），ln 转化 TC 浓度分别降低 0.15mg/dL（95%置信区间（CI）：-0.25，-0.05）、0.12mg/dL（95% CI：-0.19，-0.05）、0.12mg/dL（95% CI：-0.19，-0.05）和 0.05mg/dL（95% CI：-0.09，-0.01），ln 转化 HDL-C 浓度分别降低 0.17mg/dL（95% CI：-0.29，-0.05）、0.12mg/dL（95% CI：-0.20，-0.03）、0.12mg/dL（95% CI：-0.20，-0.03）和 0.06mg/dL（95% CI：-0.11，-0.00）。还观察到 PFDA、PFUdA 或 PFTrDA 的 ln 转化浓度与 TG 和 LDL-C 的 ln 转化脐带浓度之间存在统计学上显著的负相关关系。在 BKMR 模型中，八种 PFAS 的混合物与所有 ln 转化的脂质浓度呈暗示性的负相关，与混合物的第 75 百分位暴露相比，第 25 百分位暴露的 ln 转化 TC 浓度低 0.11 个单位（95%可信区间，-0.21，-0.01）。我们的研究结果表明，产前暴露于 PFAS 可能会干扰新生儿的脂质代谢。
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